Neuroeffector Junctions II Flashcards
What receptors contain the binding site and the end effector in the same complex?
ligand gated ion channels
This drug binds to the acetylcholine binding site, occupies it, and prevents receptor activation.
tubocurarine
Which drug is hydrolyzed by plasma esterase?
mivicurium
What is a short acting non-depolarizing muscle relaxant?
mivicurium
What non-depolarizing muscle relaxants are long acting? (2)
tubocurarine
pancuronium
What muscle relaxant leads to decreased blood pressure, bronchoconstriction, and increased danger of bronchospasm?
What kind of reaction is this?
tubocurarine
histamine release
What non-depolarizing muscle relaxant is this?
-anti-muscarinic activity leads to tachycardia
pancuronium
Non-depolarizing muscle relaxants’ effects are reversed by ________ _______.
Acetylcholinesterase inhibitors
What autoimmune disorder where patients make antibodies against muscle nicotinic receptor?
myasthenia gravis
In myasthenia gravis neuromuscular blocking drugs are less or more effective?
more
Succinylcholine is a ____ agonist at all nicotinic receptors.
partial
Succinylcholine has a longer duration of action than acetylcholine. True or false?
true
Succinylcholine is a good substrate for the cholinesterase localized within the neuromuscular junction. True or false?
false
It is a poor substrate so remains in the junction a bit longer before diffusing.
Succinylcholine remains in the junction a bit longer before it diffuses out and is hydrolyzed by _______ ______.
plasma cholinesterases
__________ initiates a depolarizing block of the postjunctional membrane.
Succinylcholine
The ______ depolarized membrane prevents recovery from ______ of Na+ channels near the endplate and sets up a localized zone of electrical inexcitability.
persistently
inactivation
Any _______ is capable of causing a depolarizing block.
cholinomimetic
Succincylcholine does cross the blood brain barrier. True or false?
false
does not
What can cause:
- increased intra-abdominal pressure occurs due to contraction of abdominal muscles
- increased potential for emesis
depolarizing muscle relaxants
Succx
What is too unstable in plasma to be an effective drug because it has both muscarinic and nicotinic (ganglion stimulant) effects?
acetylcholine
For depolarizing muscle relaxants cholinesterase inhibitors ______ the block.
deepen
