Neuroeffector Junctions II

Question 1

What receptors contain the binding site and the end effector in the same complex?

Answer 1

ligand gated ion channels

Question 2

This drug binds to the acetylcholine binding site, occupies it, and prevents receptor activation.

Answer 2

tubocurarine

Question 3

Which drug is hydrolyzed by plasma esterase?

Answer 3

mivicurium

Question 4

What is a short acting non-depolarizing muscle relaxant?

Answer 4

mivicurium

Question 5

What non-depolarizing muscle relaxants are long acting? (2)

Answer 5

tubocurarine

pancuronium

Question 6

What muscle relaxant leads to decreased blood pressure, bronchoconstriction, and increased danger of bronchospasm?

What kind of reaction is this?

Answer 6

tubocurarine

histamine release

Question 7

What non-depolarizing muscle relaxant is this?

-anti-muscarinic activity leads to tachycardia

Answer 7

pancuronium

Question 8

Non-depolarizing muscle relaxants’ effects are reversed by ________ _______.

Answer 8

Acetylcholinesterase inhibitors

Question 9

What autoimmune disorder where patients make antibodies against muscle nicotinic receptor?

Answer 9

myasthenia gravis

Question 10

In myasthenia gravis neuromuscular blocking drugs are less or more effective?

Answer 10

more

Question 11

Succinylcholine is a ____ agonist at all nicotinic receptors.

Answer 11

partial

Question 12

Succinylcholine has a longer duration of action than acetylcholine. True or false?

Answer 12

true

Question 13

Succinylcholine is a good substrate for the cholinesterase localized within the neuromuscular junction. True or false?

Answer 13

false

It is a poor substrate so remains in the junction a bit longer before diffusing.

Question 14

Succinylcholine remains in the junction a bit longer before it diffuses out and is hydrolyzed by _______ ______.

Answer 14

plasma cholinesterases

Question 15

__________ initiates a depolarizing block of the postjunctional membrane.

Answer 15

Succinylcholine

Question 16

The ______ depolarized membrane prevents recovery from ______ of Na+ channels near the endplate and sets up a localized zone of electrical inexcitability.

Answer 16

persistently

inactivation

Question 17

Any _______ is capable of causing a depolarizing block.

Answer 17

cholinomimetic

Question 18

Succincylcholine does cross the blood brain barrier. True or false?

Answer 18

false

does not

Question 19

What can cause:

• increased intra-abdominal pressure occurs due to contraction of abdominal muscles
• increased potential for emesis

Answer 19

depolarizing muscle relaxants

Succx

Question 20

What is too unstable in plasma to be an effective drug because it has both muscarinic and nicotinic (ganglion stimulant) effects?

Answer 20

acetylcholine

Question 22

For depolarizing muscle relaxants cholinesterase inhibitors ______ the block.

Answer 22

deepen