Sympatholytics

Question 1

Clonidine

Answer 1

Alpha2 agonist

Treats HTN, severe pain, ADHD

Question 2

alpha-methyldopa

Answer 2

Alpha2 agonist

Treats HTN in pregnancy

Question 3

Phenoxybenzamine

Answer 3

Nonselective alpha antagonist (irreversible; not reversed with norepingephrine)

Administered perioperatively to prevent a hypertensive crisis in patients with pheochromocytoma

Question 4

Phentolamine

Answer 4

Nonselective alpha blocker (reversible; reversible with high doses of norepinephrine)

Give to patients on MAO inhibitors who eat tyramine-containing foods; cocaine overdose

Question 5

Prazosin, terazosin, doxazosin, tamsulosin

Answer 5

Alpha1 selective blocker

Treats urinary symptoms of BPH (tamsulosin is safer to use in BPH patients with HTN)

Prazosin treats PTSD

All but tamsulosin treat HTN

Question 6

Mirtazapine

Answer 6

Alpha2 selective blocker

Treats depression

Question 7

Acebutolol, Atenolol, Betaxolol, Esmolol, Metoprolol

Answer 7

Beta1-selective antagonist

Metoprolol, carvedilol, and bisoprolol decrease mortality post-MI

Metoprolol and esmolol decrease AV conduction velocity (class II antiarrhythmics)

Question 8

Nadolol, Pindolol, Propanolol, Timolol

Answer 8

Nonselective beta-antagonist (Beta1 and Beta2 effects)

Timolol treats glaucoma (decreases secretion of aqueous tumor)

Question 9

Carvedilol, Labetalol

Answer 9

Nonselective alpha- and beta-antagonists
- do not end with “-olol”

Metoprolol, carvedilol, and bisoprolol decrease mortality post-MI