Cholinolytics

Question 1

Tropicamide

Answer 1

Muscarinic antagonist, affects eye

Produces mydriasis and cycloplegia (inhibits ciliary muscle)

Question 2

Benztropine

Answer 2

Muscarinic antagonist, affects CNS

Treats Parkinson disease

Question 3

Scopolamine

Answer 3

Muscarinic antagonist, affects CNS

Treats motion sickness

Question 4

Ipratropium, tiotropium

Answer 4

Muscarinic antagonist; affects respiratory system

Treats COPD, asthma

Question 5

Oxybutynin, darifenacin, solifenacin

Answer 5

Muscarinic antagonist; affects GU system

Reduces urgency in mild cystitis and reduces bladder spasms

Question 6

Glycopyrrolate

Answer 6

Muscarinic antagonist; affects GI and respiratory systems

Reduces airway secretions; helps to prevent drooling and peptic ulcer development

Question 7

Symptoms of atropine overdose

Answer 7

Hot as a hare (decreased sweating)
Dry as a bone (decreased secretions)
Red as a beet
Blind as a bat (cycloplegia - loss of accommodation)
Mad as a hatter (disorientation)

Question 8

Botulinum toxin

Answer 8

Blocks the release of ACh from presynaptic terminals

Question 9

Curare

Answer 9

Competes wiht ACh for receptors on the motor end plate. Decreases size of end plate potential. Max doses can produce paralysis of respiratory muscles.

Question 10

Hemicholinium

Answer 10

Blocks reuptake of choline inot presynaptic terminal –> depletes ACh stores from presynaptic terminal.