Antiprotozoan Flashcards
1
Q
Pyrimethamine and Sulfadiazine
A
Antiprotozoans used to treat Toxoplasma gondii (brain abscess in HIV seen as ring-enhancing lesions on CT/MRI)
Congenital toxoplasmosis = chorioretinitis, hydrocephalus, intracranial calcifications
Toxo arises from cats
2
Q
Chloroquine
A
Blocks detoxification of heme into hemozoin. Heme accumulates and is toxix to plasmodia
Treats plasmodial species other than P. falciparum (resistant due to membrane pump), which is treated with artemther/lumefantrine ro atovaquone/proguanil
Used quinidine for life-threatening malaria
