Drugs Reactions

Question 1

Drugs that prolong QT interval

Answer 1

“Some Risky Meds Can Prolong QT”:

• Sotalol (class III antiarrhythmic)
• Risperidone
• Macrolides
• Chloroquine
• Protease inhibitors
• Quinidine (class 1a antiarrhythmic)
• Thiazides

Question 2

Drugs that cause coronary vasospasm

Answer 2

Cocaine, sumatriptan, ergot alkaloids

Question 3

Drugs that cause cutaneous flushing

Answer 3

“VANC”:

• Vancomycin
• Adenosine
• Niacin
• Ca channel blockers

Question 4

Drugs that cause dilated cardiomyopathy

Answer 4

Doxorubicin, daunorubicin

Question 5

Drugs that cause hyperuricemia

Answer 5

• Niacin
• HCTZ
• Cyclosporine
• Pyrazinamide

Question 6

Drugs that cause hyperkalemia

Answer 6

• Nonselective beta blockers (block beta2-mediated K uptake)
• ACE inhibitors
• ARBs
• K-sparing diuretics (amiloride, triamterene, spironolactone, eplerenone)
• Cardiac glycosides (digoxin)
• NSAIDs

Question 7

HCTZ side effects

Answer 7

HYPER problems:

• Hyperuricemia
• Hypercalcemia (and hypocalciuria, good tx for nephrolithiasis)
• Hyperglycemia
• Hyperlipidemia (LDL and cholesterol)

HYPO problems:

• Hypokalemia
• Hypotension

Question 8

Substrates of cytochrome P-450

Answer 8

• Anti-epileptics
• Antidepressants
• Antipsychotics
• Anesthetics
• Theophylline
• Warfarin
• Statin
• OCPs

“Always, Always, Always Think When Starting Others”

Question 9

Inducers of cytochrome P-450

Answer 9

• Chronic alcohol use
• Modafinil
• St. John’s wort
• Phenytoin
• Phenobarbital
• Nevirapine
• Rifampin
• Griseofulvin
• Carbamazepine

“Chronic alcoholic Mona steals Phen-Phen and Never Refuses Greasy Carbs”

Question 10

Inhibitors of cytochrome P-450

Answer 10

• Acute alcohol abuse
• Gemfibrozil
• Ciprofloxacin
• Isoniazid
• Grapefruit juice
• Quinidine
• Amiodarone
• Ketoconazole
• Macrolides
• Sulfanomides
• Cimetidine
• Ritonavir

“A cute Gentleman “Cipped” Iced grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls”