Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Sympathetic NS > Flashcards

Sympathetic NS Flashcards

0
Q

What receptor does Phenylephrine act upon?

A

Alpha 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

List 4 SNS pure agonist drugs

A

Phenylephrine
Alpha methyldopa
Dopamine
Salbutamol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What receptor does Alpha methyldopa act upon?

A

Alpha 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What receptor does Dopamine act upon?

A

Beta 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What receptor does Salbutamol act upon?

A

Beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

List 4 SNS non-specific Agonist drugs

A

Ephedrine
Amphetamine
Cocaine
Adrenaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

List 4 SNS blockers

A

Doxazosin
Atenolol/bisoprolol
Propanolol
Carvedilol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name which receptor Doxazosin act upon?

A

Alpha 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What receptor does Atenolol/Bisoprolol act upon?

A

Beta 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What receptor does Propanolol act upon?

A

Beta 1 and beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What receptor does Carvedilol act upon?

A

Alpha 1, beta 1 and beta 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which drugs act upon alpha 1 receptors and what are their respective MOA?

A

Phenylephrine - SNS pure a1 agonist
Doxazosin - SNS a1 blocker
Carvedilol - SNS a1,b1,b2 blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which drugs act upon alpha 2 receptors and what are their respective MOA?

A

Alpha methyldopa - SNS pure a2 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which drugs act upon beta 2 receptors and what are their respective MOA?

A

Dopamine - SNS pure b1 agonist
Atenolol/Bisoprolol - SNS b1 blocker
Propanolol - SNS b1,b2 blocker
Carvedilol - SNS a1,b1,b2 blocker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the therapeutic effects of Phenylephrine and what it is used to treat?

A

Vasoconstriction
Increases blood pressure
Maybe mydriasis

  • Topical to nose
  • conjunctivitis
  • allergy rhinitis
  • flu (decongestant)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the therapeutic effects of Alpha Methyldopa and what it is used to treat?

A

Decreases TPR

  • Twice daily. Liver metabolism.
  • Hypertension
  • Hypertension due to pregnancy!
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the therapeutic effects of Dopamine and what it is used to treat?

A 
Increases CO (increases conductivity of SA node and increases contractility)
Increases renal perfusion
  • IV use.

Cardiogenic shock (increase CO and HR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the therapeutic effects of Salbutamol and what it is used to treat?

A

Bronchodilation in airways
Stops uterine contractions

Asthma and COPD
Premature labour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the therapeutic effects of ephedrine and what it is used to treat?

A

Vasoconstriction
Increase CO
Increase HR
Increase vessel resistance

  • Weaker than amphetamine
  • Doesn’t cross blood-brain barrier easily

Oral congestion (oral decongestant)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the MOA of phenylephrine?

A

Mimics the effects of NA and Adren. on a1 receptors in vascular smooth muscle
Increases blood pressure by vasoconstriction (can be used locally to do so)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the MOA of alpha methyldopa?

A 
Decreases presynaptic release of Na in the vasomotor centre of the brain thus increasing SNS effects
Decreases TPR (total peripheral resistance) but leaves other reflexes intact.
22
Q

What is the MOA of dopamine?

A

Mimics effects of neurotransmitters on b1 in heart and JG cells of kidney
Increases levels of cAMP
Increases O2 demand in heart
Increases conduction through the SA node

23
Q

What is the MOA of salbutamol?

A

Mimics action of adrenaline on b2 receptors in lungs, blood vessels, pregnant uterus and liver
Increases relaxation of smooth muscle (by increasing cAMP levels)

24
Q

What is the MOA of ephedrine?

A

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters
Released presynaptically by NA

25
Q

What are the therapeutic effects of amphetamine and what it is used to treat?

A

Increases SNS effects

  • Addictive (drug of abuse)
26
Q

What is the MOA of amphetamine?

A

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters (it is released presynaptically by NA)
Stimulates NA in the brain which increases dopamine levels there (addiction)

27
Q

What are the therapeutic effects of cocaine and what it is used to treat?

A

Increases SNS effects

  • Addictive (drug of abuse)
28
Q

What is the MOA of cocaine?

A

Mimics the effects of NA and Adren. on the b1 receptors in the heart and JG cells.
Increases SNS by increasing synaptic neurotransmitters as it is a re-uptake inhibitor
Stimulates NA in the brain which increases dopamine levels there (addiction)

29
Q

What is the MOA of doxazosin?

A

Blocks the binding of NA to the peripheral a1 adrenergic receptors
Competitive antagonist
Blocks SNS reflex after postural changes

30
Q

What is the MOA of atenolol/bisoprolol?

A

Blocks the effects of NA and Adren. on b1 receptors
Pure antagonist
Blocks b-cells in brain
Increases renin release in JG cells
Blocks conduction through AV node and SA node
Decreases contractility and O2 demand in heart

  • Cardioselective
  • Loses b1 selectivity at higher doses (starts blocking b2)
31
Q

What is the MOA of propanolol?

A

Blocks the effect of Na and Adren. on b1 and b2 receptors.
Pure antagonist in organs
Increases renin release in JG cells
Blocks b-cells in brain
Blocks conduction through AV node and SA node
Decreases contractility and O2 demand in heart

32
Q

What is the MOA of carvedilol?

A

Blocks the effect of NA and Adren. on b1, b2 and a1 receptors
Pure Antagonist
Blocks conduction through the AV node and SA node
Blocks action of NA on vascular smooth muscle

33
Q

What are the therapeutic effects of doxazosin and what it is used to treat?

A 
Decreases TPR (by decreasing SNS)
First dose hypotension (orthostatic or normal)
  • Once daily
  • Third line drug

Hypertension
BPH

34
Q

What are the therapeutic effects of propanolol and what it is used to treat?

A

Decreases HR
Decreases SV
Decreases O2 consumption
Decreases conduction

  • Short half-life (3-4 times daily)

Hypentension
Angina Pectoris
Supraventricular arrhythmia

35
Q

What are the therapeutic effects of atenolol/bisoprolol and what it is used to treat?

A

Decreases HR
Decreases SV
Decreases O2 consumption
Decreases conduction

  • Long half-life (1-2 times daily)

Hypentension
Angina Pectoris
Supraventricular arrhythmia

36
Q

What are the therapeutic effects of carvedilol and what it is used to treat?

A

Stops catecholamine SNS, induces remodelling
Decreases conduction

  • Must be built up in order to be used for prevent intolerance

Hypertension (in heart failure)

37
Q

List any adverse effects or contra-indications of phenylephrine?

A

Hypertension

38
Q

List any adverse effects or contra-indications of alpha methyldopa?

A

Depression

Tiredness (decreased NA in brain)

39
Q

List any adverse effects or contra-indications of dopamine?

A

Anxiety (tremor)
Arrhythmia
Heart Failure

40
Q

List any adverse effects or contra-indications of salbutamol?

A

Anxiety (tremor)
Palpitations
Tachycardia (activation of b1 receptors)

41
Q

List any adverse effects or contra-indications of ephedrine?

A

Anxiety (tremor)
Arrhythmia
Heart failure

42
Q

List any adverse effects or contra-indications of amphetamine?

A

Anxiety (tremor)
Arrhythmia
Heart failure

43
Q

List any adverse effects or contra-indications of cocaine?

A

Anxiety (tremor)
Arrhythmia
Heart failure

44
Q

List any adverse effects or contra-indications of adrenalin?

A

Anxiety (tremor)
Arrhythmia
Heart failure

45
Q

What are the therapeutic effects of adrenaline and what it is used to treat?

A 
Increases CO
Increases HR
Increases contractility (and conduction)
Incraeses O2 demand in heart
Bronchodilation (lungs)
Increases blood flow in skeletal blood vessels
  • Only IV or SC (sub-cutaneous)

Cardiogenic shock
Anaphylaxis

46
Q

What is the MOA of adrenaline?

A

mimics effect of NA on b1 adreno-receptors in heart and JG cells
Increases conduction through AV node and SA node
Increases contractility and O2 demand in heart

47
Q

List any adverse effects or contra-indications of doxazosin?

A

Depression
Tiredness (blockade of a1 receptors in brain)
Orthostatic hypotension

48
Q

List any adverse effects or contra-indications of atenolol/bisporolol?

A 
Diabetes
Heart block
Heart failure
COPD (chronic obstructive pulmonary disease)
Asthma
PVD (peripheral vascular disease)
49
Q

List any adverse effects or contra-indications of propanolol?

A 
Diabetes
Heart block
Heart failure
COPD (chronic obstructive pulmonary disease)
Asthma
PVD (peripheral vascular disease)
50
Q

List any adverse effects or contra-indications of carvedilol?

A 
Diabetes
Heart block
COPD (chronic obstructive pulmonary disease)
Asthma
PVD (peripheral vascular disease)

Pharmacology (12 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions