Other Drugs Flashcards
1
Q
What is the MOA of Fosfomycin?
A
- Inhibits early cell wall synthesis
- Bactericidal
2
Q
How is Fosfomycin eliminated?
A
- Urine
- Breast milk
3
Q
How is Fosfomycin administered?
A
- Oral
* Delayed by food (2 hours before)(3 hours after)
4
Q
What spectrum is Fosfomycin and what is it used to treat?
A
- Broad (Gram +ve and Gram -ve)
- Synergistic with B lactams, aminoglycosides and quinolones
- UTI in women/girls older than 5 years (single dose)
- Prophylaxis: diagnostic and transurethral procedures in men
5
Q
What are the side effects of Fosfomycin?
A
- GIT issues, skin rashes
6
Q
What drug interactions occur with Fosfomycin?
A
- Metoclopramide (decreases concentration)
7
Q
What is contra-indicated with Fosfomycin?
A
- Renal failure
- Pregnancy
- Lactation (excreted in breast milk)
