Surgical assessment Flashcards
What is pain:
- sensation that results from the stimulation of small afferent nerve fibres called nociceptors due to trauma
- prostaglandins cause swelling and pain
Productive vs non-productive pain:
Productive: a warning of injury, occurs upon tissue damage, immediate reaction
Non-productive: often caused by tissue injury, serves no purpose as a warning or diagnostic tool, person has little control over it
Which enzymes are blocked by NSAIDs?
COX-1
COX-2
What type of analgesic is ibuprofen?
NSAIDs (propionic acid derivative)
Actions of prostaglandins:
- signal tissue damage
- pro-inflammatory
- mediate fever and increase pain perception (CNS)
- protect the gastric mucosa
- increase platelet aggregation
Second generation NSAIDs
- block only COX-2
- purpose: reduce gastric mucosa damage side effect of NSAIDs.
- problems: increase risk of cardiovascular events, protective effect not as great as originally hoped.
Adverse effects of NSAIDs
- GI disturbance: gastritis, bleeding, nausea, diarrhoea
- skin reactions: rash, mouth soreness
- headache, dizziness, fatigue
- platelet inhibition
Reye’s Syndrome
- acquired encephalopathy of young children that follows acute febrile illness
- recurrent vomiting, agitation, lethargy
- may lead to coma and intracranial hypertension, fatty degeneration of liver
- strongly associated with aspirin use
Disease Modifying Antirheumatic Drugs (DMARDs)
- used in management of rheumatoid arthritis (methotrexate, auranofin, pencillamine, sulfasalazine)
- more toxic than NSAIDs but arrests the disease process
Mu opioid receptor mediated effects:
- analgesia
- reduced emotional distress
- sedation
- euphoria
- respiratory depression
- reduced GI motility
- pupil constriction
- decreased body temp
- dry mouth
- nausea and vomiting
Partial agonist of mu opioid receptor:
Buprenorphine
Antagonists of the mu opioid receptor:
- naloxone
- naltrexone
Tolerance of opioids:
- tolerance to one mu receptor agonist confers tolerance to other agonists
- cross tolerance across the class of drugs
Opioid-drug interactions:
- Other sedatives: high risk of respiratory depression & cognitive impairment
- antihypertensives: hypotensive effect of opioids can become significant in combination
Adverse effects of opioids:
- decreased intestinal motility: constipation
- decreased gastric emptying, urinary retention
- histamine release: bronchoconstriction
- hypotension, bradycardia
- respiratory depression
- sedation, dizziness, headache
- dependence, tolerance