Surgery Flashcards
High Risk for surgery (5)
- age >70
- Pulm: FEV1< 70, PCO2>45, pulm edema
- Cards: MI last 30 d, poor control nonsinus arrhythmia, pathologic Q waves, severe valve D+, decompensated CHF, poor EF
- Renal: Cr <2 or 50% dec from baseline
- type of surgery: vascular or anticipated large blood loss
When to get preop CXR
> 50 yrs
Pulmonary disease (smoker, COPD, MG)
Surgery >3 hrs
Agent to protect kidneys from radiocontrast
Acetylcysteine
Staph is in chain or cluster
cluster
Strep is in chain or cluster
Chain
How long to wait after epidural catheter removal before restarting warfarin?
2 hours - need to avoid formation of epidural hematoma
Cause of fever: Postop day # pneumo
Major S/S
Tx
after 3rd day
PRODUCTIVE COUGH
Abx, bronchoscopy
Cause of fever: Postop day #UTI
Major S/S
Tx
3-5 d
FOLEY CATH
Abx, remove foley
Cause of fever: Postop day # wound/cath infection
Major S/S
Tx
5-8 d
Warm, drainage
Abx, irrigation, drainage, debridement
Cause of fever: Postop day # DVT
Tx
any time
Anticoag or IVC filter
Cause of fever: Postop day # PE
Major S/S
Tx
Any time
INCREASED A-a GRADIENT
V/Q mismatch
Anticoag/IVC filter
Cause of fever: Postop day # Meds
Major S/S
Tx
Any time
New meds, think abx
Stop Rx
Cause of fever: Postop day # Transfusion reaction
Tx
any time, check with compatibility workup
Acetaminophen, diphenhydramine, stop transfusion
Postop fever 5 W
Wind- Pneumo Water- UTI Wound Wonder drug Walking- DVT, PE
Acute abdomen - previous surgery with high pitched bowel signs, crampy pain, N/V
Obstruction/strangulation 2/2 adhesions tumors hernias
Acute abdomen- LLQ pain, blood in stool
Diverticulitis
Acute Abd- hematemesis, hematochezia, sudden pain
Massive GI hemorrhage/perf
Need angiography w/ embolization
Acute abd- RLQ pain, periumbilical pain, rectal exam = tender
Appendicitis
Acute abd- severe pain out of proportion to examination
Mesenteric ischemia
Acute abd- Upper abdominal and back pain, N/V
Pancreatitis
Acute abd- amenorrhea, low abd pain
Ruptured ectopic
Acute abd- cervical motion tenderness
PID
Major causes PID
Chlamydia
N. gonorrhoeae
Cause malignant hyperthermia
Halothane
Succinylcholine
3 factors looked at when donating organs
HLA
ABO
Crossmatch compatibility - antidonor Ab on recipient T cells
Hyperacute rejection
When
Cause
Tx
Initial 24 hr - kidney turns bluish black after release vascular clamps during surgery
Antidonor Ab in recipient = preformed (type II hypersensitivity)
No Tx
Acute rejection
When
Cause
Tx
6 d-1 yr
Antidonor T cells in recipient
Reversible with immunosuppressive Rx= pulse corticosteroids, anti T cell ab (Polyclonal AB/OKT3), Ab (basilizimab, daclizumab), immunosuppressants (tracrolimus, mycophenolate, cyclosporine)
Chronic rejection
When
Cause
Tx
> 1 yr
Development of multiple cellular and humoral immune reactions to donor tissue
Not treatable, may be able to immunosuppress
Reason to transplant BM
Aplastic anemia
Induction chemo
CI heart transplant
Survival
Pulm HTN
Smoking last 6 months
5 Yrs
Reason to transplant lung
Reason to not
Survival
COPD, CF
Smoking
56% 3 yr, chronic rejection common
Reason to transplant kidney
Reason to not
Where is it placed
end stage renal disease
Not: DM and lupus- CI
In the iliac fossa
Reason to transplant pancreas
Reason to not
DM I
DM II
Mechanism cyclosporine
Adverse effects
Helper T cell inhibition via inhibition IL-2 production
Nephrotoxic, androgenic, HTN
Mechanism azothioprine
Adverse effects
Inhibit T cell proliferation via inhibition of DNA and RNA synthesis
Leukopenia
Mechanism tacrolimus
Adverse effect
Inhibitor of T cell fcn via inhibition of signaling through T cell function
Nephrotoxic, neurotoxic
Mechanism Corticosteroids
Adverse effect
Inhibits all leukocytes via inhibition of IL1 production
Cushing, weight gain, AVN of bone
Mechanism Muromonab D2 (OKT3)
Adverse effect
Inhibitor T cell fcn and depletes T cell population = good for early rejection maintenance
ONE TIME CYTOKINE RELEASE = fever and bronchospasm, leukopenia; only use short term
Rapamycin Mechanism
ADverse effect
Helper T cell inhibition
Thrombocytopenia, hyperlipidemia
Mycophenolic acid mechanism
Adverse effect
Inhibits T cell proliferation
Leukopenia, GI toxicity
Antithymocyte globulin mechanism
Adverse effect
Depletes T cell population - good for early rejection maintenance
Serum sickness, short term only
Hydroxychloroquine mechanism
Adverse effect
Inhibit antigen processing= GVH
Visual disturbances
Thalidomide mechanism
Adverse effect
Inhibits T cell fcn and migration - GVH
Sedation, constipation, teratogenic
RUQ pain
Gallbladder
Liver disease (abscess)
Fitz Hugh Curtis
Hepatic adenoma- young woman + OCP
LUQ
Spleen
PUD
RLQ
Appendix
Ileocecal - Crohn
Adnexal
Epigastric
Stomach- penetrating ulcer, gastric carcinoma
Pancreas
Diffuse
Bowel obstruction
Peritonitis
Mesenteric ischemia
Elderly pt with hypercalcemia, constipation, abdominal pain
Multiple myeloma
Adrenal masses: 3 conditions
Pheo
Cushing syndrome
Conn syndrome
Flushing, HTN, sweating
Pheochromocytoma
Moon facies, elevated serum Na, HTN, truncal obesity, ABD striae
Cushing syndrome
HTN, elevated serum Na, decreased serum K, metabolic alkalosis
Conn syndrome - secrete aldosterone
Murphy sign
Cessation of inspiration during palpation of RUQ
Cholecystitis
Labs cholelithiasis vs cholecystitis vs choledocholithiasis vs cholangitis
Cholelithiasis: no change
Cholecystitis: Inc WBC
Choledocholithiasis: Inc bili, ALP, ?AST/ALT
Cholangitis: Inc AST, ALT, bili, ALP, GGT, WBC
Hernia through inner and outer inguinal ring; is lateral to epigastric vessels and into scrotum or labial region because of patent processus vaginalis (congenital defect)
Indirect
Hernia protrudes medial to inferior epigastric vessels because of weakness in abd mm of Hesselbach triangle
Direct
Hernia through gemoral ring onto anterior thigh below inguinal ring
Femoral
Mos common in both sexes
Indirect
More common in women
Femoral
Most susceptible to incarceration and strangulation
Femoral
Incarceration vs strangulation
Incarceration: swollen and edematous, most common cause SBO if never had abd surgery and 2nd most common if have had surgery
Strangulation: blood supply cut off, necrosis can occur
Meckel can put at risk for
Volvulus
Intussusception
Dx Meckel
Technetium-99 scan
Pancreatic pseudocyst vs abscess
Pseudocyst: circumscribed peripancreatic fluid collection of pancreatic enzymes, blood, necrotic tissue (complication of pancreatitis, if severe must be drained)
Abscess: collection of pus resulting from tissue necrosis and infection that presents with abd pain, fever, leukocytosis 1-2 wks after pancreatitis; Tx drainage percutaneousl or surgically
After splenectomy, what vaccines?
H flu
Pneumococcal
Meningococcal
Open pneumothorax
Open defect in chest wall that causes poor ventilation and oxygenation
Tx: intubate, Positive P ventilation, close wound on 3 sides only - allow extra P to escape
No breathe sounds on affected side, hypertympanic on affected side, hypotension, distended neck veins
Tension pneumo
Tx tension pneumo
Needle thoracentesis 2nd intercostal space at midclavicular line w/ chest tube
Hypotension, distended neck veins, mufled heart sounds, pulsus paradoxes, normal breat sounds
Cardiac tamponade
Decreased breath sounds on affected side, dull percussion, hypotension or collapsed neck veins, tachycardia
Massive hemothorax
Risk factors Fournierβs gangrene
DM Alcohol use Immunocompromised state Recent hx indwelling catheter Perirectal infection
Tx superficial thrombophlebitis
NSAID
Localized extremity pain and redness, cordlike area of induration, erythema, tenderness
Superficial thrombophlebitis
Test for C diff colitis
Fastest
Best
Fastest: Proctoscopy
Best: C diff ELISA
Tx C diff colitis
Metronidazole first line
Vancomycin oral 2nd- expensive
Blood loss amt and % for class I, II, III, IV
1: 2000/ >40%
Transfuse stage 3&4
Basiliximab and Dacluzimab: monoclonal ab to what receptor
IL2
Methotrexate
Folic acid antagonist
OKTS Ab to what recptor
CD3 on T cells