Emergency Medicine Flashcards
Class of drugs that may cause syndrome of muscle rigidity, hyperthermia, autonomic instability, EPS
Antipsychotics- neuroleptic malingnant syndrome
Side effect of corticosteroids
Acute mania, immunosuppression, thin skin, easy bruising, myopathies
Tx DTs
BDZ
Tx acetaminophen OD
N-acetylcystein
Tx opiod overdose
Naloxone
Tx BDZ OD
Flumazenil
Tx NMS and hyperthermia
Dantrolene
Tx malignant HTN
Nitroprusside
Tx afib
Rate control, rhythm conversion, anticoagulation
Tx SVT
Stable: rate control with carotid massage or other vagal stimulation
Unsuccessful: adenosine
Causes drug induced SLE
INH Penicillamine Hydralazine Procainamide Chlorpromazine Methyldopa Quinidine
Macrocytic megaloblastic anemia with neuro Sx
B12 def
Macrocytic megaloblastic anemia w/o neuro Sx
Folate def
Burn pt with cherry red, flushed skin and coma. SaO2 normal but carboxyhemoglobin elevated. Tx
CO poisoning- 100% O2 or hyperbaric O2 if poisoning severe or pt pregnant
Blood in urethral meatus or high riding prostate or perineal ecchymosis or blood in scrotum or pelvic fx
Bladder rupture or urethral injury
Test to r/o urethral injury
Retrograde cystourethrogram
Radiographic evidence of aortic disruption or dissection
Widened mediastinum (>8 cm), loss of aortic knob, pleural cap, tracheal dev to right, depression L main stem bronchus
Radiographic indications for surgery of acute abdomen
Free air under diaphragm, extravasation of contrast, severe bowel distention, space occupying lesion on CT, mesenteric occlusion on angiography
Most common organism in burn related infection
Pseudomonas- look for fruity smell or blue green color
Method of calculating fluid replacement in burn pts
Parkland formula: 24 hr fluid = 4 x kg x % BSA
50% over first 8 hrs and rest over 16 hrs
Acceptable urine output in trauma pt
50 cc/hr
Acceptable urine output in stable pt
30 cc/hr
Signs neurogenic shock
Hypotension and bradycardia
Signs of increased ICP (Cushingβs triad)
HTN
Bradycardia
abnormal respirations
Dec CO, Dec PCWP, inc PVR
Hypovolemic shock
Dec CO, Inc PCWP, Inc PVR
Cardiogenic or obstructive shock
Inc CO, Dec PCWP, Dec PVR
Septic or anaphylactic shock
Tx septic shock
Fluids and broad spectrum abx
Give fluid until CVP=8
Pressors- NE or DA
Cultures before abc
Tx cardiogenic shock
Identify cause, pressors like dopamine if hypotensive or dobutamine if not hypotensive
Tx hypovolemic shock
Identify cause, isotonic (LR or NS) fluid and blood repletion in 3:1 ratio
NO PRESSORS
Tx anaphylactic shock
Diphenhydramine or epi 1:1000
Consider steroids
Supportive Tx ARDS
CPAP
Signs of air embolism
Pt with chest trauma who was previously stable suddenly dies
Sign of cardiac tamponade
Distended neck veins
Hypotension
Diminished heart sound (Beckβs triad)
Pulsus paradoxus
Absent breath sounds, dullness to percussion, shock, flat neck veins
Massive hemothorax
Absent breath sounds tracheal deviation, shock, distended neck veins, hyperresonance
Tension pneumothorax
Tx for blunt or penetrating ABD trauma in hemodynamically unstable pts
Immediate exploratory laparotomy
Inc ICP in alcoholics or elderly following head trauma. Can be acute or chronic, crescent shape in CT
Subdural
Head trauma with immediate loss of consciousness followed by lucid interval then rapid deterioration, Convex on CT
Epidural
ABCDE
Airway Breathing Circulation Disability Exposure
4 reasons to intubate
GCS <8
Apnea
Significantly depressed mental status
Impending airway compromise- maxillofacial trauma, inhalation injury
Tx tension pneumothorax
Immediate needle decompression w/ thoracostomy tube
CXR tension pneumo
Hyperlucent on affected side, flattening and inferior displacement of diaphragm on that side, shift of mediastinum away
Amount of blood for massive hemothorax
> 1500 cc
Replacement of fluids
3:1 ratio of fluid to blood loss Use 16 gauge IV in both arms Isotonic-LR or NS Fluid bolus 1-2 L first, recheck vitals, continue repletion Consider PRBC if hypotension
Triad cardiac tamponade
JVD
Hypotension
Muffled heart sound
Tx cardiac tamponade
Immediate pericardiocentesis
FAST scan
Focused abdominal sonography for trauma
New murmur 2/2 chest trauma
Aortic dissection
Rapid deceleration injury can causeβ¦
Coup contrecoup (bleeds where 2 impacts) Diffuse axonal injury
Punctate hemorrhage at gray white matter junction
Diffuse axonal injury
Lucid interval
Epidural hematoma
Crosses suture lines
Subdural
Does not cross suture lines
Epidural
Middle meningeal artery
Epudural
Dural bridging veins
Subdural
Most common cause aortic disruption
decel injury
CXR shows wide mediastinum, loss of aortic knob, pleural cap, deviated esophagus and trachea to R, depression L main stem bronchus
Aortic disruption
Gold standard for evaluation of aortic disruption
Aortography
Define flail chest
3+ adjacent ribs fx at 2 places
Fever Tachypnea Tachycardia Conjuctival hemorrhage UE petechiae Trauma
Fat emoblism
Kehrβs sign
Referred shoulder pain due to diaphragmatic irritation (usu on left due to spleen rupture)
Possible causes of pulseless electrical activity
Hypovolemia Hypoxia Hydrogen ions - acidosis Hyper/Hypo K+ and others Hypothermia Tablets: Drug OD Tamponade: Cardiac Tension pneumo Thrombosis: coronary Thrombosis: PE
Peritoneal lavage
Saline infused by catheter into ABD and removed and examined- find blood or fecal matter
When to do exparatory lap
Penetrating abd trauma
Intra-abd bleeding or visceral damage
Retroperitoneal hematoms in upper abdomen
SVT
Unstable: synchronized electrical cardioversion
Stable: control rate (Valsalva, carotid sinus massage, cold stimulus)
Resistant to maneuvers: adenosine followed by other AV nodal blocking agents - CCB or Beta blockers
Afib/aflutter
Unstable: synchronized electrical cardioversion 120-200J
Stable: control rate with diltiazem or Beta blockers and anticoagulate if >48 hrs duration
Elective cardioversion if <48 hrs; otherwise must anticoagulate or do TEE
NO NODAL BLOCKERS- WPW; procainamide is better
Bradycardia
Sx: atropine
Ineffective: transcutaneous pacing, dopamine, epi
Abdominal pain that is sharp and focal with tenderness and guarding
Pts do not want to move
Parietal/peritoneal
Abdominal pain that is dully, crampy, achy, midline or diffuse
Pt unable to lie still
Visceral/organ
Abrupt, excruciating pain
Biliary colic- RUQ MI: substrnal Perforated ulcer: epigastric Ureteral colic: LQ Ruptured aneurysm: umbilical
Rapid onset of severe, constant pain
Acute pancreatitis: epigastric
Mesenteric thrombosis, strangulated bowel- umbilical
Ectopic pregnancy- deep LQ
Intermittent colicky pain crescendo with free intervals
Early pancreatitis-epigastric
SBO-umbilical
IBS-suprapubic and middle of LQ
Gradual steady pain
Acute cholecystitis, acute cholangitis, acute hepatitis: RUQ
Appendicitis, acute salpignitis: RLQ
Diverticulitis: LLQ
Positive beta hCG with shock
ruptured ectopic until prove otherwise
Abdominal pain + syncope or shock in older pt
AAA until proven otherwise
Cervical motion tenderness
Consider PID
Sudden onset of diffuse, severe abdominal pain w/ abdominal rigidity
Perforation
Acute onset of severe radiating colicky pain
Obstipation (not pass stool or gas)
Bilious emesis
Obstruction
Constant, ill-defined pain with gradual onset over 10-12 hrs
Inflammation
Associated Sx of anorexia, N/V, changes in bowel habits, hematochezia, melena suggest what etiology?
GI
Fever and cough suggest what etiology
Pneumonia
Hematuria, pyuria, CVA tenderness suggest what etiology?
GU
Assocaited with meals
Mesenteric ischemia-elderly or w/ CAD or PAD PUD Biliary disease Pancreatitis Bowel pathology
FH of abdominal pain
Familial Mediterranean fever
Acute intermittent porphyria
Hx AF or recent AAA repair, bloody stool,sudden onset abdominal pain out of proportion to physical findings
Ischemic colitis
Psoas sign
Passive extension of hip leads to RLQ pain
Obturator sign
Passive IR of flexed hip leads to RLQ pain
Rosvingβs sign
Deep palpation of LLQ leads to RLQ pain
Hamburger sign
Pt wants to eat- consider something other than appendicitis
Pt populations with atypical S/S during acute appendicitis
Children
Elderly
Pregnant
Retrocecal appendices
Dx tests for appendicitis
CT with IV and PO contrast- highly sensitive for periappendiceal stranding or fluid
US: enlarged noncompressible- kids and preggers
How to estimate BSA in burn patients
Adults vs kid
Rule of 9's Adult: Head and each arm = 9% Back and chest each: 18% Each leg = 18% Perineum =1%
Kids: Head 18% Arm- 9% each legs-14% each trunk and back: 18% each
Second leading cause of death in kids
Burns
First degree burn
Epidermis only
Painful, erythematous
NO BLISTERS,
Good cap refill
Second degree burn
Epi and partial dermis
Painful w/ blisters
Third degree
Epi and full dermis, potentially deeper
Painless, white, cleared
Major complications of burns
Shock Compartment syndrome Superinfection- Pseudomonas or Gram P cocci Stress ulcer-Curling Aspiration Dehydration Ileus Renal insufficiency- 2/2 rhabdomyolsysis Epithelial contractions
6 W of Postop fever
Wind: atelectasis, pneumonia Water: UTI Wounds: infection/abscess Walking: DVT Wonder drug Womb: endometritis
Fevers before postop day? usually not infectious
Exception?
Post day 3
Clostridium or Beta hemolytic strep
Cause malignant hyperthermia
Halothane
CAuse NMS
S/S, labs
Neuroleptic agents
Mental status change, inc creatinine phosphokinase
What measure is not beneficial in CO poisoning?
O2 sat- measure carboxyHg as normally saturated = not reflect low arterial PO2 levels
Bees and wasps stings
Complication
Tx
Anaphylaxis
Tx: antihistamine, steroid, IM epi for anaphylaxis
Black widow bites
Complication
Tx
Mm pain and spasms, localized diaphoresis, ABD pain, inc ANS = ileus, CV collapse, hemolytic anemia, DIC, rhabdo
Tx: antivenin, wound care, BDZ
Scorpions
Complication
Tx
CN dysfcn (severe), excessive motor activity, resp compromise, acute pancreatitis, myocardial toxicity Tx: Support w/ BDZ/phenobarb and analgesics, atropine for hypersalivation and resp distress, IV ab, Antivenin
Snakes bites
Complications
Tx
Progressive dyspnea, DIC 2/2 toxin
Tx: Antivenom
Elevate affected limb
Dogs and cats bites
Complications
Tx
Infection, rabies, tetanus= Staph, Pasteurella multocida possible infection
Tx: amoxicillin, clavulanate; saline irrigation, debridement, tetanus and rabies prophy
Humans bites Tx
Amoxicillin clavulanate, saline irrigation, debridement
Rodents bite Tx
Local wound care- low risk infection
May carry rabies
Rabies
What carries
Prophy
BATS
If animal showed signs rabies give 1 dose human rabies Ig and 4 doses rabies vaccine over 14 d; if vaccinated need 2 dose vaccine
Tetanus Tx
Previous dose /=3:
- Clean, minor: vaccine only if last was >/= 10 yrs prior
- All other: vaccine only if last >/= 10 yrs ago
Normal levels carboxyHg smoker vs non
Smoker <5%
Induction of P 450
Queen Barb Steals Phenphen and Refuses Greasy Carbs Quinidine Barbs St Johns Wort Phenytoin Rifampin Griseofulvin Carbamazepine
Inhibition P450
Cimetidine Ketoconazole INH Grapefruit Erythromycin Sulfonamides
Metabolism by _ 450
BDZ, barbs Amide anesthetics Metoprolo, Propranolol Nifedipine Phenytoin Quinidine Theophylline Warfarin
Increased risk dig toxicity
Quinidine
Cimetidine
Amiodarone
CCB
Competition for albumin binding sites
Warfarin
ASA
Phenytoin
Blood dyscrasias
Ibuprofen
Quinidine
Methyldopa
Chemotherapeutic agents
Hemolysis in G6PD def
Sulfonamides INH ASA Nitrofurantoin Primaquine Pyrimethamine Chloramphenicol
Gynecomastia
Some Excellent Drugs Create Awesome Knockers Spironolactone Estrogens Digitalis Cimetidine chronic Alcohol use Ketoconazole
SJS
Anticonvulsants
sulfonamides
Penicllins
Photosensitiviy
Tetracycline
AMiodarone
Sulfonamides
Drug induced SLE
Procainamide Hydralazine INH Penicillamine Methyldopa Quinidine
Antidote acetaminophen
Sx OD
N-acetylcysteine
Sx: N, hepatic insufficiency
Antidote acid or alkali ingestion
Upper endoscopy for stricture
Antidote anticholinesterase
SX
Physostigmine
Sx: Dry mouth, urinary retention, QRS widening
Antidote arsenic, mercury, gold
Sx
Succimer
Dimercaprol
Sx: renal insuff, tremor, mental status changes
Antidote Beta blockers
Sx
Glucagon, calcium, insulin, dextrose
Sx: bradycardia, hypotension, hypoglycemia, pulmonary edema
Antidote Barbs (phenobarb)
Urine alkalinization
Dialysis
Activated charcoal
Support
Antidote BDZ
Sx
Flumazenil- can precipitate withdrawal
Sx: Sedation, resp depression
Antidote Black widow bite
Calcium gluconate, methocarbamol
Antidote CO
100% O2/hyperbaric
Antidote Copper, arsenic, lead, gold
Penicillamine
Antidote cyanide
hydroxycobalamin
Amyl nitrate
Na nitrate
Na thiosulfate
Antidote digitalis
Sx
Normalize K but avoid giving Ca or Mg or lido (for torsade)
anti-digitalis Fab
Sx: N/V, changes vision, arrhyhtmias
Antidote heparin
Protamine sulfate
Antidote INH
Sz
pyrodoxine (B6)
Sx: neuropathy, hepatoxicity
Antidote iron salt
Sx
Deferoxamine
Sx: nausea, constipation, hepatotoxicitiy
Antidote Lead
Sx
Succumer
CaEDTA
Dimercaprol
Sx: peripheral neuropathy, anemia
Antidote methanol/ethylene glycol
Sx
EtOH
Fomepizole
Dialysis
Ca gluconate for ethylene glycol
Sx: HA, vision changes, dizziness- methanol
Sx: ataxia, hallucinations, seizures, SWEET BREATH- ethylene glycol
Antidote methemoglobin
Methylene blu
Antidote Opiods
Sx
Naloxone
Sx: pinpoint pupils, resp depression
Antidote Salicylates
Sx
urine alkinization, dialysis, activated charcoal
Sx: N/V, tinnitus, hyperventilation, anion gap, metabolic acidosis
Antidote TCA
Sx
Na bicarb for QRS prolongation
Diazepam or lorazepam for seizures
Cardiac monitor for dysrhythmias
Sx: Tachycardia, dry mouth, urinary retention, QRS widening
Antidote Theophylline
Activated charcoal
Consider repeat doses
Antidote tPA, streptokinase
Aminocaproic acid
Antidote warfarin
Vit K
FFP
Side effect ACEI
COUGH Rash Proteinuria Angioedema Taste changes TERATOGEN
Side effect amantadine
Ataxia LIVEDO RETICULARIS (lace like purplish discoloration of skin 2/2 venule inflammation)
Side effect Amiodarone
Acute: AV block, hypotension, bradycardia,
Chronic: pulm fibrosis, peripheral deposits leading to bluish discoloration, arrhythmias, hypo/hyperthyroidism, corneal deposits
Side effect Amphotericin
Fever/ rigors, nephrotoxic, bone marrow suppression, anemia
Side effect antipsychotics
SEdation, acute dystonic reaction, akathisia, parkisonism, tardice dyskinesia
NMS
Side effect azoles
Inhibit P450
Side effect AZT
thrombocytopenia, megaloblastic anemia
Side effect beta blockers
AStham exacerbation, masking hypoglycemia, importence, bradycardia, AV block, CHF
Side effect BDZ
sedation, dependence, respiratory depression
Side effect Bile acid resin
GI upset, malabsorption vit and minerals
Side effect Carbamazepine
Induction P450, agranulocytosis, aplastic anemia, liver toxicity
Side effect CCB
peripheral edema, constipation, cardiac depression
Side effect Chloramphenicol
GRAY BABY SYNDROME
aplastic anemia
Side effect Cisplatin
Nephrotoxic, acoustic nerve damage
Side effect clonidine
dry mouth
SEVRE REBOUND HA AND HTN
Side effect clozapine
Agranulocytosis
Side effect corticosteroids
mania, hyperglycemia, immunosuppression, bone mineral loss, thin skin, easy bruising, myopathy, cataract
Side effect cyclophosphamide
HEMORRHAGIC CYSTITIS
myleosuppression
Side effect digoxin
YELLOW VISUAL CHANGES
ARRHYTHMIAS
GI
Side effect doxorubicin
CARDIOTOXIC-CMP
Side effect ethyl alcohol
Acidosi, renal dysfunction, CNS depression
Side effect fluoroquinolones
Cartilage damage in kids
Achilles tendon rupture adults
Side effect furosemide
Ototoxic
Hypokalemia
Nephritis
Gout
Side effect gemfibroxzil
Myositis, reversible inc LFT
Side effect halothane
MALIGNANT HYPERTHERMIA
hepatotoxic
Side effect HCTZ
HypoK, hypoNa, hyperuricemia, hyperglycemia, hypercalcemia
Side effect statin
Myositis, reversible inc LFT
Side effect Hydralazinw
Drug induced SLE
Side effect hydroxychloroquine
Retinopathy
Side effect INH
Peripheral neuropathy (prevent pyridoxin/B6), hepatotoxic, inhibit P450, seizure in OD, hemolysis in G6PD def
Side effect MAOI
HYPERSENSITIVE TYRAMINE REACTION SEROTONIN SYNDROME (w/ meperidine)
Side effect Methanol
Blindnes, ion gap metabolic acidosis
Side effect Methotrexate
Hepatic fibrosis, penumonitis, anemia
Side effect Methyldopa
+ Coombs, drug induced SLE
Side effect metronidazole
Disulfuram reaction, vestibular dysfucntion, metallic taste
Side effect Niacin
FLUSHING
Side effect penicillamine
Drug induced SLE
Side effect penicillins/beta lactam
Hypersensitivity
Side effect Phenytoin
Nystagmus, diplopia, ataxia, arrhythmia, GINGIVAL HYPERPLASIA, hirsutism, teratogen
Side effect prazosin
First dose hypotension
Side effect procainamide
drug induced SLE
Side effect propylthiouracil
Agranulocytosis
Aplastic anemia
Side effect quinidine
cinchomism (HA, tinnitus), thrombocytopenia, arrhythmia- TORSDAES
Side effect Reserpine
Depression
Side effect rifampin
induction P450 enzymes
ORANGE RED BODY SECRETIONS
Side effect salicylates
Fever, hyperventilation wit RESPIRATORY ALKALOSIS AND METABOLIC ACIDOSIS, dehydration, hemorrhagic gastritis
Side effect SSRI
Anxiety, 5HT syndrome with MAOI
SEXUAL DYSFUNCTION
Side effect succinylcholine
MALIGNANT HYPERTHERMIA
HyperK
Side effect TCA
Sedation, comia, antichol, seizures, arrhythmia
QRS PROLONGATION
Side effect Tetracycline
Tooth discoloration, photosensitivity, Fanconiβs, GI
Side effect Trimethoprim
Megaloblastic anemia, leukpenia, granulocytopenia
Side effect Valproic acid
Teratogen- neural tube defect
Rare fatal hepatotoxicity
Side effect Vancomycin
Nephrotoxic, ototoxic
RED MAN SYNDROME- histamine release
Side effect Vinblastine
Severe myelosuppresion
Side effect Vincristine
Peripheral neuropathy, paralytic ileus
Tremor (6-12 hrs)
Tachycardia, HTN, agitation, seizure (48hrs)
Hallucinations
Alcohol withdrawal
Severe autonomic instability leading to tachycardia, HTN, delirium and possibly death within 2-7 d
DT
Tx Etoh withdrawal
BDZ
Haloperidol hallucinations
Thiamine, folate, multivitamin
Anxiety, seizures, delirium, tremor, tachycardia, HTN
barbs withdrawal
Tx barb withdrawal
BDZ
Rebound anxiety, seizures, tremor, insomnia
BDZ withdrawal
Tx BDZ withdrawal
BDZ taper
Depression, hyperphagia, hypersomnolence
Cocaine/amphetamine withdrawal
Tx cocaine or amphetamine withdrawal
Supportive
Avoid pure beta blockers which can lead to unopposed alpha activity = HTN
Anxiety, insomnia, flu like Sx, piloerection, fever, rhinorrhea, lacrimation, yawning, nausea, stomach cramps, diarrhea, mydriasis
Opiod withdrawal
Tx opiod withdrawal
Antiemetics
MM relaxers
NSAID
Clonidine, buprenorphine, or metadone if severe to mod Sx
Vit def: night blindness and dry skin, Bitot spots (debris on conjunctiva)
Vit A
Vit def: beriberi (polyneuritis, dilated CMP, high output CHF, edema), Wernicke Korsakoff
VIt B1 thiamine
Wet beriberi: high output cardiac failure
dry beriberi: peripheral neuropathy
Vit def: Angular stomatitis, chelitis, corneal vascularization, dermatitis
Vit B2 riboflavin
Vit def: Pellagra- diarrhea, dermatitis, dementia
Vit B3 niacin
Vit def: Dermatitis, enteritis, alopecia, adrenal insuff
Vit B5 pantothenate
Vit def: Convulsions, hyperirritability, microcytic anemia, seborrheic dermatitis, stomatitis, cheilosis; required w/ INH
Vit B6 pyridoxine
Vit def: Macrocytic megaloblastic anemia, neuro Sx (optic neuropathy, subacute combined degneration, paresthesias), glossitis
Vit B12 cobalmin
Vit def: Scurvy, poor wound healing, hyperkeratotic hair follicles, bone pain (2/2 periosteal hemorrhages)
Vit C
Vit def: Rickets in kids, osteomalacia in adults, hypocalcemic tetany
Vit D
IVit def: increased RBC fragility, anemia
Vit E
Neonatal hemorrhage, Inc PT and aPTT, Vit def: normal BT
VIt K
Vit def: Dermatitis, enteritis; can be caused by ingestion of raw eggs or antibiotic use
Biotin
Vit def: MOST COMMON VIT DEF, sprue, macrocytic megaloblastic anemia without neuro
Folate
Vit def: Weakness, mm cramps, exacerbation hypocalcemic tetany, CNS hyperirritability lead ing to tremors, choreoarthertoid movement
Magnesium
Vit def: Keshan disease -CMP
Selenium
β4th degree burnβ
electrical burns - may injure bone, mm, other internal structures
May have cardiac (vfib) or neuro Sx (seizure, loss of vision)
When inpatient for burns
2nd degree over >10% body
3rd degree >2% body
2nd or 3rd-face, gentile, hands, major flexion creases
When to intubate 3rd and 2nd degree burns
> 25% BSA or face
Risk factors mortality in burns
> 60 yrs
40% BSA
Inhalation
more factors - more risk = 0.3% (0 risk), 3% (1), 33%(2), 90%(3)
Salt water vs fresh water drowning
Fresh: hypotonic fluid absorbed into vasculature = DECREASED electrolyte conc and RBC lysis
Salt: hypertonic fluid creates osmotic gradient draws fluid from pulm capillaries into alveoli and causes PULMONARY EDEMA and INCREASED electrolyte conc
Most common location aspirated items that pass beyond trachea
Right main stem bronchus = greater vertical orientation
Hypothermia
Temperature?
Risks
EKG
<95/35
old, intoxication
EKG: J waves (end of QRS complex), Vtach or Vfib
Brown recluse bite
Complication
Tx
Possible ulceration and necrosis = ileus, CV collapse, hemolytic anemia, DIC, rhabdo
TX: wound care, dapsone to prevent tissue necrosis
When to not use charcoal
Metals
Alcohols
Antidote CCB
Sx
Glucagon, insulin, dextrose (like Beta blockers)
Sx: bradycardia, hypotension
Antidote cocaine
Sx
Support
Sx: tachycardia, agitation
Antidote isopropyl alcohol
Sx
Ethanol, fomepizole, dialysis
Sx: decreased consciousness, N, abd pain
Antidote sulfonylureas
Sx
Octreotide, dextrose
Sx: hypoglycemia
Antidote organophosphates
Sx
Atropine, pralidoxime, support
Sx: DUMBBELSS
Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation of skeletal mm, lacrimation, sweating, salivation
CAN ABSORB THROUGH SKIN- REMOVE CLOTHING
Cardiac arrest lasting longer than ? = brain death
10 minutes
Low retroperitoneal bleeding - tx
Angiography and emoblization if blunt
Lap if penetrating
12 Ps neuro exam
Paired ocular movement Papilledema Patellar and other reflexes Paralysis Paresthesias Pee (incontinence) Pressure (blood and intracranial) Psych (mental status) Ptosis Pulse rate Pupils Pyramidal signs
Sites of significant (1500 mL) blood loss not found on PE
Injury scene Pleural cavity- See with OCR Intra-Abd- CT or US Pelvic-CT Thighs- X-ray
Swan Ganz catheter
Where inserted, where sits, what measures
Inserted: left subclvian, right internal jugular
Sits: RA and pulm A
Measures: PCWP = LA P, may measure CO, mixed venous O2 sat, systemic vascular resistance
When to use whole blood
Severe blood loss- rarely used
When to use PRBCS
Low HCT 2/2 blood loss or anemia
When to use autologous blood?
What is it?
Elective surgery or chemo
Blood donated by pt, frozen until needed
When to use FFP?
Warfarin OD
Clotting factor def
DIC
TTP
When to use cryoprecipitate?
What is it?
Smaller volume than FFP, preferable to FFP in cases where large transfusion V warranted
-Clotting factor and vWF rich precipitate collected during thawing of FFP
When to use platelets
Thrombocytopenia not due to rapid platelet destruction
When to use clotting factors
Specfic deficience - hemophilia
Vasopressor anaphylactic shock
Epi
Vasopressor shcok (Renal sparing)
DA
Vasopressor CHG
Dobutamine
Anticholinergic crisis
Blind as a bat- eye mm not focus Hot as a hare Mad as a hatter Dry as a bone Red as a beet Dilated pupils and increased HR (Anti muscarinic and Anti nicotinic meds)
Causes disulfiram like reaction
Metronidazole
Cephalosporins
Aspiration pneumo cause alcoholics
Klebsiella
Alcoholic: how to not precipitate wernicke
Thiamine before glucose- b1 used in glc metabolism
Currant jelly sputum
Klebsiella
Wernicke vs korsakoff
AWernicke: acute encephalopatyh - opthalmoplegia, nystagmus, ataxia, or confusion
Korsakoff: chronic psychosis - anterograde amnesia, confabulation, irreversible
Area of brain affected by Korsakoff
Mamillary bodies and thalamic nuclei
Vit def causes wernicke and korsakoff
Thiamine/ B1
Mineral def: microcytic anemia, koilonychia (spoon shaped fingernails)
Iron
Mineral def: goiter, cretinism, hypothyroidism
Iodine
Mineral def: dental caries
Fluorine
Mineral def: Hypogeusia (dec taste), rash, slow wound healing
Zinc
Mineral def: menkes disease - Xlinked, kinky hair, mental retardation
Copper
Mineral def: CMP and mm pain
Selenium
Mineral def: impaired glc tolerance
Chromium
Vit toxicity: pseudotumor cerebri, bone thickening, teratogen
Vit A
Vit toxicity: hypercalcemia, N/V, renal toxicity
Vit D
Vit toxicity: Necrotizing enterocolitis in infants
Vit E
Vit toxicity: hemolysis β>kernicterus
Vit K
Vit toxicity: peripheral neuropathy
Vit b6
Mineral toxicity: hemochromatosis
Iron
Mineral toxicity: Myxedema
Iodine
Mineral toxicity: flurosis with mottling of teeth and bone exostoses
Fluorine
Mineral toxicity: Wilson
Copper
Mineral toxicity: Loss of hair and nails
Selenium
Mineral toxicity: miners ore causes βmadnessβ
Manganese
Conditions associated with pernicious anemia
What is pernicious anemia
What: antiparietal cell Ab destroy ability to secrete IF
DM I, vitiligo, hypothyroidism
Removal of ileum, IBD
Tapeworm causes B12 def
Diphyllobothrium latum