superficial and deep mycoses Flashcards
mahor fungi that cause only stat corneum hair nail infection
dermatophytes
3 genera of dermatophytes
Microsporum
trichophyton
epidermophyton
what blood type in dermstophyte infection are prone to chronic disease
Blood type a
hairy areas usual mode of tx?
Oral therapy
inhibitioj if cytochrome P450 14Alpha demethylase . drug
Imidazoles
anpolyebe works by irreversible binding to ergosterol used for candida infections. not for dermatophytes
nystatin
allylamines- naftifi ne; terbinafine; butenafinez MOA
inhibition of squalene epoxydation.
affect CYP450
triazole: itraconazole; fluconazole.
drug where fatty food inc absorption.
Itraconazole and griseofulvin.
lowered absorption due to antacids; h2 antagonists; ppi.
itraconzaole
ketoconazole.
IKA
terbinafine is less active again:st what dpecie
Candida and microsporum.
TCM
ketoconazole side effect
Wide spec of action on dermatophytes yeast and systemic mycoses.
but has potential for hepatotoxicity.
fluconazole mainly for
candida.
also in dermatophytes.
T capitis tx and age group
Griseofulvin in children over 2.
Terbinafine over 4.
itraconazole SE
heart failure
Voriconazole has activity on?
Side effects
Yeasts. and other fungal pathogens.
SE: Pppasm
Photosensitivity premature photoaging porphyria actinic keratoses scc melanoma
posaconazole has significant invitro activity against
Candida spp
Echinocandins moa
Inhibit B 1,3 glucan synthesis. thus damaging fungal walls.
effective on candida, fungistatic againts aspergillus sp.
1st drug in echinocandin class marketed in us for refractory invasive aspergillosis
Caspofungin
