superficial and deep mycoses

Question 1

mahor fungi that cause only stat corneum hair nail infection

Answer 1

dermatophytes

Question 2

3 genera of dermatophytes

Answer 2

Microsporum
trichophyton
epidermophyton

Question 3

what blood type in dermstophyte infection are prone to chronic disease

Answer 3

Blood type a

Question 4

hairy areas usual mode of tx?

Answer 4

Oral therapy

Question 5

inhibitioj if cytochrome P450 14Alpha demethylase . drug

Answer 5

Imidazoles

Question 6

anpolyebe works by irreversible binding to ergosterol used for candida infections. not for dermatophytes

Answer 6

nystatin

Question 7

allylamines- naftifi ne; terbinafine; butenafinez MOA

Answer 7

inhibition of squalene epoxydation.

Question 8

affect CYP450

Answer 8

triazole: itraconazole; fluconazole.

Question 9

drug where fatty food inc absorption.

Answer 9

Itraconazole and griseofulvin.

Question 10

lowered absorption due to antacids; h2 antagonists; ppi.

Answer 10

itraconzaole
ketoconazole.

IKA

Question 11

terbinafine is less active again:st what dpecie

Answer 11

Candida and microsporum.

TCM

Question 12

ketoconazole side effect

Answer 12

Wide spec of action on dermatophytes yeast and systemic mycoses.
but has potential for hepatotoxicity.

Question 13

fluconazole mainly for

Answer 13

candida.

also in dermatophytes.

Question 14

T capitis tx and age group

Answer 14

Griseofulvin in children over 2.

Terbinafine over 4.

Question 15

itraconazole SE

Answer 15

heart failure

Question 16

Voriconazole has activity on?

Side effects

Answer 16

Yeasts. and other fungal pathogens.

SE: Pppasm

Photosensitivity
premature photoaging 
porphyria 
actinic keratoses 
scc
melanoma

Question 17

posaconazole has significant invitro activity against

Answer 17

Candida spp

Question 18

Echinocandins moa

Answer 18

Inhibit B 1,3 glucan synthesis. thus damaging fungal walls.

effective on candida, fungistatic againts aspergillus sp.

Question 19

1st drug in echinocandin class marketed in us for refractory invasive aspergillosis

Answer 19

Caspofungin