Superfamily Filarioidea Flashcards
Give 4 characteristics of Superfamily Filarioidea
- Indirect life cycle
- None inhabit the alimentary tract
- All depend on insect vectors (ih)
- Usually lay larvae (mff) which develop to L3
What is the common name for Dirofilaria Immitis?
Heartworm
Who are the hosts for Dirofilaria Immitis?
Dogs and Cats
Is heartworm disease zoonotic?
Yes!
Who are the intermediate host for Dirofilaria immitis?
Mosquitoes
What are the characteristic features of Dirofilaria Immitis?
Adults are long and slender, 20-30 cm. Size and site specific. Characteristic microfilariae (mff) L1 around 300 micrometers long
What can you see in this image?
Dirofilaria Immitis mff in blood spear
What can you diagnose about this image?
Dirofilaria Immitis infestation known as heartworm disease
Describe the life cycle of Dirofilaria Immitis.
Adult females release mff L1 into bloodstream -> mosquito ingests mff with blood meal -> mff L1 develop into infective stage L3 in mosquito -> Mosquito bites dog or cat and transmits infective L3 -> within a few days L3 molt to L4 -> L4 migrate through SQ tissue of abdomen and thorax for 2-3 months before molting into L5 -> L5 enter a vein and are carried to pulmonary arteries to develop into sexually mature adults -> in 2-3 months adult females release mff in blood. PPP 6-9 months
Where are the sites of infection for Dirofilaria Immitis?
Adults in distal parts of pulmonary arteries. When large numbers are present, right heart and caudal vena cava
What are the pathogenesis and lesions of Dirofilaria Immitis?
Endothelium is destroyed, fluid leakage (thrombus formation), tortuous arteries, increased resistance, post-caval syndrome, Wolbachia spp. (bacteria) are harbored by D. Immitis (administer Doxycycline)
What are the clinical signs for D. Immitis?
Severity of clinical disease is determined by pulmonary blood flow not by the number of nematodes present.
Signalment - large outdoor males (moving around a lot)
History - asymptomatic, cough, exercise intolerance
Physical examination - abnormalities vary
How is D. Immitis diagnosed?
Remember, long PPP so must know life cycle.
Antigen test: sexually mature females
Mff tests: complements antigen test
Occult infections
Other blood tests
Radiology and Echocardiography
How can you prevent D. Immitis infection?
DEC (Diethylcarbamazine), Macrocyclic Lactones (ivermectin, selamectin) - effective against L3 and L4. DEC is given orally daily. MCLs may have additional prevention against external and internal parasites.
How is D. Immitis treated?
Improve clinical condition of animal, remove ALL life stages of heartworms. Begin animal on prophylaxis, Doxycycline, kill mff, manage clinical signs, adulticide therapy, and cage rest. Finally, mosquito control