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PHM 602- Diabetes > Sulfonylureas DI > Flashcards

Sulfonylureas DI Flashcards

1
Q

Sulfonylurea MoA

A

Stimulate insulin release from beta cells

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2
Q

SUs site of action

A

Beta cells

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3
Q

SU products

A

Glyburide, glipizide, glimepiride

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4
Q

Glyburide brand names

A

DiaBeta, Micronase, Glynase Prestabs

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5
Q

Glipizide brand names

A

Glucotrol, Glucotrol XL

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6
Q

Glimepiride brand name

A

Amaryl

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7
Q

Glyburide dosing

A

1.25-20mg PO daily, MDD 20mg

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8
Q

Glipizide dosing

A

IR: 2.5-20mg PO once or twice daily, MDD 40mg

If daily dose is >15mg, divide into BID dosing

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9
Q

Glimepiride dosing

A

1-4mg PO daily, MDD 8mg

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10
Q

SUs on the Beers list

A

Glyburide, glimepiride

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11
Q

SU side effects

A

HYPOGLYCEMIA, N/V, weight gain

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12
Q

SU drug interaction

A

Alcohol- avoid alcohol!

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13
Q

SU contraindication

A

CrCl <50 mL/min (glyburide only), hypersensitivity, DKA, T1DM, glyburide and glipizide are CI’ed in pregnancy near term

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14
Q

SU precautions

A

Sulfonamide allergy, elderly, impaired liver and renal function

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15
Q

SU counseling points

A

Take first thing in the morning with breakfast or the first meal of the day

If it upsets your stomach- take it with food

Avoid alcohol

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16
Q

What do you ask about at every refill of a SU?

A

Hypoglycemia and weight gain

17
Q

SU A1C lowering

A

High (0.8-2%)

18
Q

SU effect on ASCVD, CKD, HF

A

Neutral, don’t affect HF, CKD, ASCVD

19
Q

SU monitoring

A

Hypoglycemia, FBG, A1C, weight gain, allergic reactions, sun sensitivity

20
Q

SU time to full effect

A

4-6 weeks

21
Q

ADA guidelines for SUs

A

Use when cost is a major issue

22
Q

AACE guidelines for SUs

A

Last-line option for monotherapy, but somewhere in the middle for dual and triple therapy (it’s not your last-line option but it’s also not your first choice)

23
Q

Renal dosing for SUs

A

(This dosing isn’t recommended)

Glyburide: CrCl <50
Glimepiride: eGFR <15
Glipizide: eGFR <10

PHM 602- Diabetes (19 decks)

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