GLP-1 RA DI

Question 1

GLP-1 RA MoA

Answer 1

suppresses glucagon secretion, increases insulin secretion, slows gastric emptying, promotes beta-cell proliferation

Question 2

GLP-1 RA drugs with daily dosing

Answer 2

Exenatide (Byetta), Liraglutide (Victoza), Lixisenatide (Adylxin), PO semaglutide (Rybelsus)

Question 3

GLP-1 RA drugs with weekly dosing

Answer 3

Exenatide (Bydureon, Bydureon BCise), dulaglutide (Trulicity), SQ semaglutide (Ozempic)

Question 4

Exenatide brand names

Answer 4

Byetta (once daily), Bydureon, Bydureon BCise (once weekly)

Question 5

Liraglutide brand name

Answer 5

Victoza

Question 6

Lixisenatide brand name

Answer 6

Adylxin

Question 7

Semaglutide brand names

Answer 7

Rybelsus (PO), Ozempic (SQ)

Question 8

Dulaglutide brand name

Answer 8

Trulicity

Question 9

Byetta dosing

Answer 9

5mcg SQ QD

Question 10

Liraglutide dosing

Answer 10

0.6mg SQ

Question 11

Lixisenatide dosing

Answer 11

10mcg SQ for 14 days, then 20mcg

Question 12

Rybelsus dosing

Answer 12

3mg PO for 30 days, then 7mg PO, then 14mg PO

Question 13

Bydureon dosing

Answer 13

2mg weekly

Question 14

Dulaglutide dosing

Answer 14

0.75mg weekly, then 1.5mg, then 3mg, then 4.5mg

Question 15

Ozempic dosing

Answer 15

0.25mg weekly, then 0.5mg, then 1mg

Question 16

Pre-filled multiple dose pens

Answer 16

Byetta, Victoza, Adylxin, Ozempic

Question 17

Pre-filled single-use pens

Answer 17

Bydureon, Trulicity

Question 18

GLP-1 RA side effects

Answer 18

N/V/D, GERD, dyspepsia

Question 19

GLP-1 RA BBW

Answer 19

thyroid C-cell tumor/cancer (lixisenatide is the only one that doesn’t have this BBW)

Question 20

GLP-1 RA CI

Answer 20

Severe GI disease, CrCl <30 mL/min for exenatide

Question 21

GLP-1 RA counseling

Answer 21

May cause upset stomach but should go away over time, store in fridge before use but leave at room temperature after first use, take Rybelsus 30 minutes before first meal, take with as little water as possible

Question 22

What should you ask about at GLP-1 RA refills?

Answer 22

GI upset and dose timing

Question 23

GLP-1 RA pearls

Answer 23

High A1C lowering, no hypoglycemia, weight LOSS, neutral effect on HF, improved renal outcomes with liraglutide and dulaglutide

Question 24

GLP-1 RA renal dosing

Answer 24

Exenatide and lixisenatide

Question 25

GLP-1 RAs that are effective in Black patients

Answer 25

Lixisenatide and semaglutide

Question 26

GLP-1 RA monitoring

Answer 26

A1C, FBG/PPG, renal function, GI symptoms, patient use of device

Question 27

GLP-1 RA peak effect

Answer 27

6-8 weeks

Question 28

ADA guidelines on GLP-1 RA

Answer 28

Use when ASCVD risk is present, to minimize hypoglycemia, and weight loss

Question 29

AACE guidelines on GLP-1 RA

Answer 29

Second-line after metformin