Gliptins/DPP4i DI

Question 1

DPP4i MoA

Answer 1

potentiate effects of incretin hormones

Question 2

DPP4i drugs

Answer 2

Sitagliptin (Januvia)
Saxagliptin (Onglyza)
Linagliptin (Tradjenta)
Alogliptin (Nesina)

Question 3

Brand name for sitagliptin

Answer 3

Januvia

Question 4

Brand name for saxagliptin

Answer 4

Onglyza

Question 5

Brand name for linagliptin

Answer 5

Tradjenta

Question 6

Brand name for alogliptin

Answer 6

Nesina

Question 7

DPP4i side effects

Answer 7

nasopharyngitis, URI

Question 8

DPP4i precaution

Answer 8

HF, use with GLP-1RA

Question 9

DPP4i counseling

Answer 9

Take once a day at the same time each day, can be taken with or without food, avoid alcohol

Question 10

What should you ask about at DPP4i refills?

Answer 10

URI and nasopharyngitis

Question 11

DPP4i clinical pearls

Answer 11

Intermediate A1C lowering, neutral weight gain, neutral ASCVD and CKD effects, increased HF risk with saxagliptin and alogliptin

Question 12

Renal dosing in DPP4is

Answer 12

All require renal dosing except for linagliptin

Question 13

DPP4i monitoring

Answer 13

A1C, FBG/PPG, URI, GI disturbances

Question 14

DPP4i peak effect

Answer 14

6-8 weeks

Question 15

DPP4is in ADA guidelines

Answer 15

Used to minimize hypoglycemia

Question 16

DPP4is in AACE guidelines

Answer 16

4th-line option after metformin, GLP-1 RA, SGLT2is

Question 17

Sitagliptin dosing

Answer 17

100mg QD

Question 18

Linagliptin dosing

Answer 18

5mg QD

Question 19

Saxagliptin dosing

Answer 19

5mg QD

Question 20

Alogliptin dosing

Answer 20

25mg QD