alpha-Glucosidase Inhibitors (AGI) DI

Question 1

AGI MoA

Answer 1

Decreases breakdown of sucrose and complex carbs in the brush border of the small intestine

Question 2

AGI drugs

Answer 2

Acarbose (Precose), miglitol (Glyset)

Question 3

Brand name for acarbose

Answer 3

Precose

Question 4

Brand name for miglitol

Answer 4

Glyset

Question 5

Acarbose dosing

Answer 5

25mg PO TID, MDD 50mg PO TID

Question 6

Miglitol dosing

Answer 6

25mg PO TID, MDD 100mg PO TID

Question 7

AGI side effects

Answer 7

GI disturbances, weight gain

Question 8

AGI CI

Answer 8

Any GI complications

Question 9

AGI counseling

Answer 9

start low and go slow to avoid GI side effects, take with first bite of each meal- skip meal, skip dose! Ask about GI upset

Question 10

AGI pearls

Answer 10

High A1C lowering but only for patients whose diets mostly consist of complex carbs, neutral effect on ASCVD, CKD, HF

Question 11

AGI monitoring

Answer 11

PPG, A1C, GI side effects

Question 12

AGI peak effect

Answer 12

4-6 weeks

Question 13

AGI in ADA guidelines

Answer 13

They’re not mentioned anywhere

Question 14

AGI in AACE guidelines

Answer 14

Last-line option