sulfonamides Flashcards
sulfonamides are primarily used for:
UTIs
name the sulfonamides:
sulfadiazine silver sulfadizine sulfisoxazole sulfamethoxazole sulfacetamide
sulfamethoxazole + trimethoprim
mechanism of sulfonamides
bacteriostatic
reversible inhibitor of folic acid synthesis
dihydropteroate synthethase inhibtor
sulfadiazine treats
UTI
silver sulfadizine - use
topic antibiotic for wound management
which sulfonamide is used for ear infections
sulfisoxazole
which sulfonamide is used for eye infections (drops) and rosaciae (topical)
sulfacetamide
trimethoprim + sulfamethoxazole - mechanism
inhibit folic acid synthesis
trimethoprim - inhibits dihydrofolate reductase
sulfamethoxazole - inhibits dihydropteroate synthetase
-two sequential steps in the production of folic acid
bacteriostatic?
sulfonamides - side efects
stephen johnsons syndrom (hypersensitivty) renal crystalluria bone marrow suppression hemolytic anemia protein binding drug interactions
which sulfonamide has the least risk for renal crystalluria
sulfisoxazole
- chloramphenicol - mechainsm
bacteriostatic
binds 50S ribosome
- chloramphenicol - use
broad spectrum against gram - microorganisms
rickettsiae
- chloramphenicol - toxicity
gray baby syndrome
hematological toxicity, bone marrow suppresion
hypersensitivity reactions
