quinolones

Question 1

mechanism of quinolones

Answer 1

binds to DNA gyrase and topo IV (not found in mammalian cells)
blocks DNA rep

bactericidal

Question 2

first generation quinolone

Answer 2

nalidixic acid

Question 3

naldixic acid - use

Answer 3

limited to treatment of UTIs

narrow gram - spectrum

Question 4

second generation quinolones

Answer 4

ciprofloxacin

norfloxacin

Question 5

second gen (ciprofloxacin, norfloxacin) - use

Answer 5

increased gram - activity, some gram +
chlamydia, mycoplasma (bacteria without cell wall)
UTI
GI
STD
skin infections
gram - osteomyelitis
S pnemonae resistance

Question 6

third gen quinolones

Answer 6

levofloxacin

Question 7

levofloxacin - use

Answer 7

broader gram + - spectrum
chlamydia, mycoplasm, strep pneumonae, meningitis by H influenzae
infection of sinuses, skin, lungs, ear, airway, bone, joints

communciable bacterial infections

Question 8

fourth gen quinolone

Answer 8

moxifloxacin

Question 9

moxifloxacin - use

Answer 9

added anaerobic coverage
poor pseudomonas coverage
NOT used for UTI, not excreted in urine

Question 10

which classes of drugs cant be taken with antacids or milk

Answer 10

tetracyclines

quinolones

Question 11

quinolones - toxicity

Answer 11

gi toxicity
CNS tox
phototoxicity
arthralgias
tendonitis
potentiates warfarin
QT interval prolongation