SUD 8

Question 1

What dissociative hallucinogen is diverted by people who work in a Vet’s office?

Answer 1

Ketamine - bc it is still used an an anesthetic for animals.

Question 2

The effects of Ketamine are similar to what other drug but much less intense and shorter in duration?

Answer 2

PCP

Question 3

LSD is one of the strongest mood-altering drugs that have an unpredictable psychological effect and variable hallucinations…

What are the physical effects seen during intoxication?

Answer 3

• Tachycardia
• Hyperthermia
• HTN
• insomnia
• loss of appetite

Question 4

What cough medicine ingredient can be abused as a hallucinogen with effects similar to PCP and Ketamine?

What is the MOA of this drug?

Answer 4

DXM (Dextromethorphan)

MOA = NMDA receptor Antagonist

(same as PCP)

Question 5

What is the treatment of PCP intoxication?

Answer 5

Supportive, can use Diazepam or BZDs to help with agitation and prevent seizures.

Question 6

What is Hallucinogen Persisting Perceptual Disorder (HPPD)?

TRX?

Answer 6

The re-experiencing of perceptual disturbance even after stopping hallucinogens. Can occur after one time use or after chronic use.

NO TRX.

Question 7

Inhalant abuse is the highest among which age group?

Answer 7

8-17 years old.

Question 8

Animal models show that what CNS changes with chronic MDMA use?

Answer 8

• Decreased Serotonin

- Degenerated Serotonin neurons

Question 9

What are the Stages of Change?

Answer 9

1. Pre-contemplation - No intention of changing
2. Contemplation - Aware of problem but no commitment to action.
3. Preparation- Intent on taking action
4. Action - active modification of behavior
5. Maintenance - sustained new behavior
6. Relapse

Question 10

What are the principles of 12-Step program?

Answer 10

1. Mutual help/positive role modeling
2. Group affiliation
3. Identification
4. Spirituality and belief in “higher power.”
5. Pragmatism - doing what works
6. Cognitive restructuring - addressing cognitive distortions caused by “alcoholic thinking” = immaturity, selfishness, irresponsibility.

Question 11

Thiamine deficiency in Wernikes is associated with what area of the brain?

Answer 11

Mamillary Bodies.

Question 12

How can Disulfiram lead to psychosis?

Answer 12

Disulfiram inhibits Dopamine beta hydroxylase, thus can increase levels of DA and cause psychosis.