SUD 4 Flashcards
What NTs are most involved in the effects of Ecstacy (methylenedioxymethamphetamine)
Serotonin *** and Dopamine
(ecstacy is a unique amphetamine in that it also acts via Serotonin system, rather the DA system alone like most other amphetamines)
How long after your last drink is DTs most likely to develop?
Onset is 2-3 days, but can last as long as 10 days.
Generally think 3-10 days.
Which on is higher in etoh use disorder…ALT or AST?
AST> ALT
Mnemonic “Alcoholism Sucks” in AST
- What lab test is helpful in detecting heavy etoh consumption (analogous to HbA1c in DM)?
- What lab test is a biomarker for alcohol use and is helpful to see if patient has been abstinent (in situations where abstinence is prohibited (air pilots in recovery, etc.)
- CDT (Carbohydrate deficient transferrin)
2. Ethyl Glucuronide (EthG) - metabolite of etoh that can be detected in urine up to 5 days after last drink.
How long after your last drink do you see a peak incidence of seizures?
At 24 hours.
Think 12-24 hours
What three BZDs undergo metabolism outside the liver so can be helpful in etoh detox where there is suspected liver disease?
Oxazepam
Temazepam
Lorazepam
“Out The Liver”
Which area of the brain is damaged in a person with alcoholism who is showing signs of Wernike/Korsakoff?
Mamillary Bodies
What is the MOA of Disulfiram?
What builds up to cause the horrible symptoms of Disulfiram?
BLOCKS Aldehyde dehydrogenase ( which converts Acetaldehyde to Acetate)
Acetaldehyde builds up causing S/S.
What medication if given with Disulfiram can cause a reaction like you drank alcohol?
Metronidazole
How long of a washout period do you want after drinking etoh can you start Disulfiram?
2 weeks.
According to CDC how many deaths per year is attributed to cigarette smoking?
1/2 million
