Succinylcholine/ Anectine

Question 0

Mech of action

Answer 0

Nicotinic ACh R-agonist > competes with ACh at neuromuscular junction; when bound causes initial wave of widespread neuromuscular depolarization and prevents ACh binding and skeletal muscle stimulation.

Question 1

Class

Answer 1

Depolarizing neuromuscular blocker

Question 2

Pharmacokinetics

Answer 2

Onset- 45-60 seconds IV, 2-3 minutes IM
Peak- 1-3 minutes
Duration- 6-10 minutes IV, 10-30 minutes IM
HL- 5-10 minutes

Question 3

Indications

Answer 3

Need for temporary paralysis to facilitate endotracheal intubation

Question 4

Contraindications

Answer 4

Penetrating eye injuries, narrow angle glaucoma
Known or suspected hyperkalemia
History of malignant hyperthermia
History of myasthenia gravis

Question 5

Side effects

Answer 5

Dysrythmias, bradycardia, hypotension, increased intraocular pressure, increased ICP

Question 6

Dose

Answer 6

Adult- 1-2 mg/kg IV, IO

Pedi- 1 mg/kg

Question 7

Precautions

Answer 7

May cause dysrhythmias and cardiac arrest, particularly in patients with hyperkalemia.

Question 8

Drug - Drug

Answer 8

Potentiated by lidocaine, procainamide, B blockers, mag sulfate, and other neuromuscular blockers