Rocuronium/ Zemuron

Question 0

Mech of action

Answer 0

Nicotinic ACh R antagonist > competes with ACh at neuromuscular junction and prevents binding thus inhibiting skeletal muscle depolarization.

Question 1

Class

Answer 1

Non-depolarizing neuromuscular blocker

Question 2

Pharmakokinetics

Answer 2

Onset- 60-70 seconds
Peak- 1-3 minutes
Duration- 25-40 minutes
HL- 14-18 minutes

Question 3

Indicatons

Answer 3

Need for temporary paralysis to facilitate endotracheal intubation
Need for continued paralysis following endotracheal intubation

Question 4

Contraindications

Answer 4

Hypersensitivity

Question 5

Side effects

Answer 5

Tachycardia, hypertension, hypotension, bronchospasm(rarely)

Question 6

Dose

Answer 6

Adult- 0.6-1.2 mg/kg IV, IO

Pedi- 0.6 mg/kg IV, IO

Question 7

Precautions

Answer 7

Presence of neuromuscular diseases may be associated with prolonged paralysis

Question 8

Drug - Drug

Answer 8

Potentiated by lidocaine, prcainamide, B blockers, K-sparing diuretics, mag sulfate, and other neuromuscular blockers including succinylcholine