Substance Related Disorders Flashcards

1
Q

Substance use that has not met criteria for dependence but has
resulted in impairment

A

Substance Abuse

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2
Q

development of a reversible change with use of a substance

A

Intoxication

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3
Q

Substance Abuse Diagnosis Criteria

Maladaptive pattern of substance use leading to impairment or
distress, characterized by 1 or more of the following symptoms in a
12 month period:

A

Recurrent substance use leads to failure of major obligations (home, school, work)

Repeated substance use in situations in which it is physically hazardous

Recurrent substance-related legal problems

Continued substance use despite having persistent or recurrent social or interpersonal problems caused by or exacerbated by the effects of the substance

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4
Q

Substance Dependence Diagnosis Criteria

Maladaptive pattern of substance use leading to impairment or distress, characterized by 3 or more of the following symptoms in a 12 month period:

A

Tolerance (need for more or diminished effect)

Withdrawal (characteristic syndrome or avoidance of symptoms)

Substance taken in larger amounts or over a longer period than intended

Persistent desire or unsuccessful efforts to cut down or control substance use

Great deal of time spent obtaining, using, or recovering from effects of the substance

Important social, occupational, or recreational activities are given up or reduced because of substance use

Substance use continued despite knowledge of having a persistent or recurrent physical or psychological problem that was likely caused or exacerbated by the substance

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5
Q

Withdrawal Diagnosis Criteria

Withdrawal, as manifested by either of the following:

2 or more of the following, developing within several hours to a few days of reduction in heavy or prolonged substance use:

A

Sweating or rapid pulse

Increased hand tremor

Nausea or vomiting

Insomnia

Physical agitation

Anxiety

Transient visual, tactile, or auditory hallucinations or illusions

Grand mal seizures

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6
Q

List some risk factors for prescription drug abuse

A

Past or present addictions to other substances, including alcohol

Younger age (Specifically the teens or early 20s)

Exposure to peer pressure or a social environment where there’s drug
use

Easy access to prescription drugs (such as working in a healthcare
setting)

Lack of knowledge about prescription drugs, or thinking that taking
someone else’s prescription drug is safe because it was prescribed by
a doctor

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7
Q

What is the most commonly abused substance in the US?

A

alcohol

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8
Q

What is the most common non-hereditary cause of mental
retardation?

A

Alcohol use in pregnancy

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9
Q

Guidelines - men and women

Moderate Drinking

A

No more than 1 drink per day for women

No more than 2 drinks per day for men

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10
Q

Guidelines - men and women

Binge Drinking

A

≥ 4 drinks for women

≥ 5 drinks for men

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11
Q

What are some differentials to consider for intoxication?

A

Hypoglycemia
Hypoxia
Drug overdose
Ethylene glycol or methanol poisoning
Hepatic encephalopathy
Psychosis
Psychomotor seizures

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12
Q

Describe the alcohol withdrawal timeline

A

Onset in 12-24 hours after last drink with peak intensity at 24-48 hours

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13
Q

How long does alcohol withdrawal tend to last?

A

Typically lasts 4-7 days

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14
Q

When does alcohol withdrawal peak?

A

Peak in 2nd day of absence,

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15
Q

What is the most severe form of alcohol withdrawal?

A

Delirium tremens

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16
Q

What is the best predictor for delirium tremens?

A

a seizure

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17
Q

What is the usual time frame to see delirium tremens post withdrawal?

A

shows up about 72 hours after last drink

18
Q

What is the DOC for delirium tremens?

A

BZs

19
Q

What is the mortality rate for untreated delirium tremens?

A

15-20%

20
Q

What is the mortality rate for treated delirium tremens?

A

~5%

21
Q

What is the definition of delirium tremens?

A

acute organic psychosis that usually manifests within 24-72 hours after the last drink

22
Q

List some signs/symptoms of delirium tremens

A

Delirium
Tremors
Seizures
Visual hallucinations
Mental confusion
Sensory hyperactivity
Autonomic hyperactivity
Dehydration
CV abnormalities
Electrolyte disturbances (hypokalemia, hypomagnesiumeia)

23
Q

What symptoms are seen in Wernicke-Korsakoff syndrome?

A

Impaired recent memory

Anterograde amnesia

Confabulation

24
Q

What is a good screening tool for alcohol abuse?

A

CAGE Questionnaire

25
Q

What are the questions in the CAGE Questionnaire?

A

C – cut down
Have you felt the need to cut down?

A – annoyed
Have you felt annoyed by criticism of drinking?

G – guilty
Have you felt guilty about your drinking?

E – eye opener
Have you had a morning eye opener?

26
Q

What should be given to patients to prevent Wernicke’s
encephalopathy, especially before giving glucose?

A

Thiamine

27
Q

What are the essential vitamin and mineral supplementation needed in chronic alcohol abuse?

A

Thiamine
Folate
B6
Magnesium

28
Q

Why is magnesium important to supplement in alcoholics?

A

Alcoholics chronically deficient

Also an essential cofactor in thiamine metabolism

29
Q

Describe the opium withdrawal timeline

A

Begins in 8 hours and lasts up to 3 days (within one week)

30
Q

Describe the cocaine withdrawal timeline

A

Symptoms last 1-2 weeks and are predominately psychosocial

31
Q

What factors are unique to marijuana that are different from other drugs?

A

no overdose

no toxic effect

No true withdrawal syndrome or dependence

32
Q

What is the estimated percentage of people in the US have used prescription drugs for non medical reasons?

A

20%

33
Q

What are four classes of medication that can lead to addition?

A

Opioids
Anxielytics (BZs)
Stimulants
Sedatives-hypnotics

34
Q

In a BZ overdose use, what should you give a patient?

A

Flumazenil

35
Q

What is the primary addicting substance in cigarettes?

A

nicotine

36
Q

Describe the cigarette withdrawal timeline

A

Onset of symptoms 2-3 hours after last tobacco use with peak in 2-3
days, resolution in 1 month of quitting

37
Q

Assess dependence level and suggest dosing using what tool?

A

Fagerstrom questionairre

38
Q

In intervention, describe the FRAMES method components

A

Offer FEEDBACK
Emphasize personal RESPONSIBILITY
Give ADVICE
Provide a MENU of options
Use EMPATHY
Support SELF-efficacy

39
Q

What are some effective medications for the treatment of opiate addiction?

A

Methadone
buprenorphine
naltrexone

40
Q

What are the two prescription medications FDA approved for tobacco addiction?

A

Bupropion

Varenicline (Chantix) – most effective drug available