Substance Abuse Flashcards
Substance abuse is a type of _______.
behaviour
Substance abuse is
the use of drugs in a non-prescribed manner or disapproved of by society. It could be recreation use (i.e. non medicinal drugs).
It is often associated with negative social and personal problems. It is not necessarily accompanied by dependence (e.g. social drinkers are not necessarily dependent on alcohol) BUT abuse carries a risk of dependence and/ or addiction
Dependence is a type of _____.
state
Physical dependence is
an altered state involving physical dependence when use of drug is suspended. Body NEEDS it in order to function to the new normal state. Can be intense. Can result in vomiting, nausea, headache
Psychological dependence is
a state involving drive requiring periodic or continuous use of drug in order to produce pleasure or avoid discomfort (withdrawal anxiety)
Addiction is a type of _______
disorder
Addiction is characterised by:
Treatment often requires
- abuse and dependence
- compulsive and uncontrollable drug seeking
- persistence in the face of negative consequences
- relapsing disorder
more than treatment of the dependent state
morphine, heroin:
primary target =
action on target =
mu opioid receptor
agonist
ketamine, PCP:
primary target =
action on target =
NMDA- receptor
blocks the ion channel
cocaine:
primary target =
action on target =
DA transporter
blocks reuptake
amphetamine, MDMA (ecstacy)
primary target =
action on target =
DA and 5-HT transporter
stimulates release and reverses action of transporter
alcohol:
primary target =
action on target =
ion channels
mimics glutamate antagonists and GABA agonists
nicotine:
primary target =
action on target =
nACh receptor
agonist
THC:
primary target =
action on target =
CB1 receptor
partial agonist
What are the four common behavioural actions of abused drugs?
- Subjective effects
- Reinforcing effects
- Tolerance
- Sensitisation
What are subjective effects?
ALL drugs of abuse produce subjective effects. These are feelings that are produced by drugs. It is one of the main reasons for drug abuse e.g. euphoria produced by opioids/ stimulants. However, subjective effects are not ALWAYS pleasurable e.g ketamine can produce euphoria & dysphoria. Subjective effect, itself, does not predict the addiction potential. e.g. k receptor agonist are not abused but can often ‘flag’ it up
Subjective effect; what role does it have in drug taking? There are 4 stages:
- initiation; curious about effects
- continued; desire to re-experience
- tolerance; euphoria produced by stimulants/ opioids leads to dose escalation, greater frequency
- internal cues; triggers contribute to bingeing, lack of control and craving for more drug.
What is polydrug abuse
This when drugs are mixed to enhance pleasurable effects or to reduce aversive effects. It creates a unique subjective experience and can be done by mixing stimulants and opioids
In pre-clinical studies, subjective effects are modelled using a technique called ____ ________
drug discrimination
Explain drug as reinforcers
Drugs are said to be reinforcers when they maintain a behaviour above the level obtained with placebo e.g. gin is a reinforcing drug because it maintains drinking behaviour above tonic alone