Substance Abuse Flashcards
What is the historical context of psychoactive substance use?
Psychoactive substances have been taken for centuries, but misuse has become a significant societal problem.
What percentage of disability adjusted life years is attributed to illicit drug use disorder and alcohol use disorder according to Whiteford et al?
Illicit drug use disorder accounts for 10% and alcohol use disorder for 9.6%.
How many drug misuse deaths involving illegal drugs were reported in England and Wales in 2016?
There were 2,593 drug misuse deaths involving illegal drugs in England and Wales in 2016.
What is the estimated annual cost of substance use disorders (SUDs) to the UK economy?
The estimated annual cost of SUDs to the UK economy is £15.4 billion.
What percentage of UK adults have taken drugs in the last year?
8.4% of UK adults have taken drugs in the last year.
What percentage of UK adults consume alcohol?
60% of adults in the UK drank alcohol.
What are the methods of administering psychoactive substances?
Psychoactive substances can be administered orally, smoked, inhaled, snorted, or injected.
What must psychoactive substances do to exert an effect?
They must reach the brain, which involves crossing the blood-brain barrier (BBB).
How do lipid-soluble chemicals affect the blood-brain barrier?
Lipid-soluble chemicals cross the blood-brain barrier more quickly.
What are the effects of drugs on the nervous system?
Drugs can affect neural membranes throughout the CNS or influence specific types of neurons.
What is the role of enzymes in drug metabolism?
Enzymes made by the liver terminate drug action by converting drugs into forms that can’t cross the BBB.
What are synthetic cannabinoids (SC)?
SC are cannabinoid receptor agonists sold as legal highs, more potent than THC and less predictable.
What are the reported hazards of synthetic cannabinoids?
Hazards include arrhythmias, myocardial infarction, sudden cardiac arrest, and psychosis.
What is addiction?
Addiction is when drug use reaches a point where the drugged state is considered normal.
What is physical dependence?
Physical dependence is the presence of a drug needed to function normally, with withdrawal symptoms when use ceases.