Studies/Trials Flashcards
(TAP) Treatment of ARMD with photodynamic therapy trial.
What was the objective and conclusions?
To evaluate verteporfin(visudyne) OPT in the management of subfoveal CNV with some classic characteristics.
Visudyne OPT is recommended for subfoveal, predominantly classic CNV.
Verteporfin in photodynamic therapy(VIP)
What was the objective and conclusions?
Visudyne OPT is recommended in the management of subfoveal occult but not classic CNV where there is evidence of recent disease progression.
(BVOS) Branch Retinal Vein Occlusion Study
What was the objective and conclusions?
Evaluate the role of photocoagulation in prevention of VH and neovascularization
Grid pattern laser in eyes with a BVO of 3-18 months with VA of 20/40 or worse and FA documented ME without foveal hemorrhage.
Perform PRP if retinal neovascularization develops especially if > or= 5 DD of non perfusion.
BRAVO study
What was the objective and conclusions?
To asses the safety/efficacy of ranibizumab(lucentis) in ME secondary to a BRVO
Ranibizumab is safe and effective in BRVO
CVOS central vein occlusion study
What was the objective and conclusions?
To evaluate pts with a CVO for: 1. Course of perfused vs nonperfused(>10 DD of nonperfusion) 3. Does early PRP Prevent NVI. 4. Is Early PRP more effective than delayed PRP at preventing NVG
No benefit of early PRP in nonperfused so wait for first signs of NVI
No benefit from focal for ME after CVO
PRP for any NVG or 2 clock hours of NVI in nonperfused.
COMS (collaborative ocular melanoma study)
What was the objective and conclusions?
Objective: To evaluate treatment options for choroidal malignant melanoma
Conclusions: Small tumor(apical 1-3mm high basal diameter 5-16mm) have a low risk of death within 5 years
