STS/MCT

Question 1

Sanchez, JAVMA, 2017:
Diphenhydramine hydrochloride during MCT excision
Effects on mean and diastolic arterial blood pressures?
Any benefits?

Answer 1

Sanchez, JAVMA, 2017:
Mean and diastolic arterial blood pressures were significantly lower
No benefits

Question 2

Karbe
Scar Revisions in Cutaneous MCT
VetSurg 2021

Answer 2

Residual disease 27%

Incomplete after revision 8%

Local reoccurrence 4% at 555d
Dz progression 15% at 207d
*neither associated with margin status or presence of MCT in resected scar

Grade III
~Lymph node metastasis
~locoregional recurrence
~disease progression

Question 3

Milovancev
Reduction in margin length after excision MCT & STS
VetSurg 2018

Answer 3

Maximum reduction in total length of margins

29. 6 mm MCT
30. 2 mm STS

Question 4

Lapsley
Locoregional aspiration vs. sentinel lymph node mapping for MCT
VetSurg 2021

Answer 4

Sentinel lymph nodes were consistently identified with ICTL ~differed from LRLN 25%

Altered recommendations
50%

Question 5

Villedieu
Pulmonary nodules in STS
JAVMA 2021

Answer 5

Pulmonary nodules in 12%

Grade 1: 6%
Grade 2: 6%
Grade 3: 38%

Increased odds of pulmonary nodules
~Grade 3 vs. 1 or 2
~Duration of STS > 3 m

*low-yield diagnostic procedure

Question 6

Ferrari et al VetSurg 2020
Using sentinel’s lymph node mapping in dogs with MCT, what percentage of sentinel lymph nodes did not correlate with the expected lymph node?

Answer 6

63%

Question 7

Crownshaw et al JAVMA 2020
What variables were associated with negative outcome for dogs with incompletely excised high grade soft tissue sarcomas treated with radiation therapy?

Answer 7

1. Increased length of surgical scar
2. Increased length of radiation treatment - important to avoid delays in treatment whenever possible

Question 8

Milovancev et al VetSurg 2018
What is the maximum reduction in total length of margins from in vivo to histologically tumor free margins for MCT and STS?

Answer 8

MCT 29.6mm
STS 24.2mm