Splenic Masses Flashcards

1
Q

Lynch, JAVMA, 2017:
What % of the malignant tumors were HSA?
What % of dogs received transfusions?
Which dogs were more likely to receive transfusions?
Overall mortality rate and mortality rates for dogs that received transfusions vs dogs that did not receive transfusions?
The odds of spontaneous death and euthanasia during hospitalization were higher for dogs that underwent transfusion - true or false?

A

Lynch, JAVMA, 2017:
76% of the malignant tumors were HSA
44% received transfusions
Dogs with malignant disease, especially dogs with HSA, were more likely to receive transfusions
Overall mortality rate: 8%
Mortality rate for dogs that received transfusions: 14%
Mortality rate for dogs that did not receive transfusions: 3%
True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Moore, JAVMA, 2017:
Stage II splenic HSA
What % of dogs were anemic before splenectomy?
What was associated with survival time?

A

Moore, JAVMA, 2017:
85% were anemic before splenectomy
Mitotic score was associated with survival time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ciepluch, Vet Surg, 2018:
What % had gross metastatic lesions?
What factors were associated with a shorter DFI?
What was associated with a longer DFI?
Effect of chemotherapy on DFI?

A

Ciepluch, Vet Surg, 2018:
45% had gross metastatic lesions
Presence of gross metastatic lesions at the time of surgery and administration of allogeneic blood products were associated with a shorter DFI
Administration of Yunnan Baiyao was associated with a longer DFI
Chemo was not associated with a shorter DFI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fleming
Small vs. Large dogs with hemoperitoneum
VetSurg 2018

A

Splenic hemorrhage
43% small
61% large

Small dogs Hemorrhage

spleen: Small < Large
liver: Small > Large
another: Small > Large

HSA associated with splenic hemorrhage
Large > Small

cut off 20 kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Story
Small breed dogs splenic HSA
VetSurg 2020

A

MST
~small 116d
~large 97d
*metastatic disease decreased survival time

Survival time of surgery and chemo
~small 207d
~large 139d
*administration of chem increased survival time in small breed

DFI
~small 446d
~large 80d
*dog size significant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Sirochman
Bipolar sealing device in splenectomy
VetSurg 2020

A

Short term mortality 11%
7% died prior to discharge
3% died prior to suture removal

Prior to discharge associated with
~administartion of blood
~increased duration of anesthesia
~intra-op V-tach

Prior to suture removal associated with
~administration of blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Schick
HSA prediction model
JVECC 2019

A

Bodyweight
Total Solids
Plt Count
Thoracic Radiographs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Clarke
Utility of liver biopsy in splenectomy
JSAP 2020

A

Abnormalities noted in
normal-appearing liver 3%
abnormal appearing liver 29%

Haemoabdomen associated with an increased likelihood of liver neoplasia on biopsy at the time of splenectomy.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Corbin
Splenomegaly in small breed
JAVMA 2017

A

less than 16 kg
~50/50 malignant

HSA 67% of malignancies

WHWT more likely to have neoplasia

Malignancy & Hemoabdomen
= decreased survival time

Malignancy is not associated with hemoperitoneum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Phipps
TEG and splenectomy
JAVMA 2020

A

Thrombocytosis and TEG suggestive of hypercoagulopathy increased from day 2 after surgery until at least 2 weeks PO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Masyr
Prognosis HSA
JAVMA 2021

A

Thrombocytopenia negative associated with
~Progression Free Interval
~Overall ST

Stage 3 HSA negative associated with
~Progression Free Interval
~Overall ST

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Burgess
Calculator for splenic mass malignancy
JAVMA 2021

A
~Serum TP
~Presence of > 2 nRBC/100 WBC
~AUS splenic mass diameter
~# liver nodules 0, 1, >2
~Presence of multiple splenic masses
~splenic mass inhomogeneity
~abdoimnal effusion
~mesenteric, omental, peritoneal nodules
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mayhew et al VetSurg 2018

For which cases may single-port laparoscopic splenectomy be appropirate?

A

smaller dogs

Small to modest (<2cm) splenic masses

Diffuse splenic disese

Not obese patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Del Busto et al JVIM 2020 What factors were associated with increased risk of postoperative death following surgical treatment of insulinoma?

A
  1. Development of post operative pancreatitis
  2. Postoperative hypoglycemia
  3. Postoperative hyperglycemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ciepluch et al VetSurg 2018 What factors were associated with decreased survival for HSA? What factors were associated with prolonged survival?

A

Decreased survival - presence of metastasis, administration of blood products -Prolonged survival - Yunnan Baiyao

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Sirochman et al VetSurg 2020 What factors were associated with death prior to discharge for splenectomies?

A
  1. Administration of blood products
  2. Increasing duration of anesthesia
  3. Intraoperative ventricular arrhythmias
17
Q

Fleming et al VetSurg 2018

Describe the differences in sources of hemoperitoneum in small vs large dogs.

A

Large dogs - more likely to be spleen 61%

Small dogs - more likely to be liver vs spleen

Other sources - retroperitoneal, etc more likely in smaller dogs

18
Q

Story et al VetSurg 2020

How is the survival time for spelnic HSA different for small dogs vs large dogs

A

No difference between groups

No difference with the addition of chemotherapy

19
Q

Story et al VetSurg 2020

What is the difference in disease free interval for small vs large dogs with splenic HSA?

A

DFI 446 days for small dogs, 80 days for large dogs

Chemotherapy improved survival time for small dogs but not larger dogs

Dog size associated with DFI but not surivival time

20
Q

Moore et al JAVMA 2017

What factor was associated wtih prolonged survival for stage II HSA?

A

Lower mitotic score