STS Flashcards
What was the outcome of a study applying definitve RT with or without Chemo after incompletley excised high grade STS?
(Crownshaw, JAVMA, 2020)
MST <3 years
1, 3 and 5-year survival rate: 85%, 43%, 18%
24% (1/4) metastasis
20% local recurrance
diesase progression was associated with increasing MI
death was associated with RT duration and lenght of the scar
The benefit of chemotherapy is unclear
In case of STS, is it possible to leave the skin, which is overlying the tumor and as such perform less aggressiv surgery?
(Del magno, VCO, 2021)
No, in 52% of the cases the skin was infiltrated above the tumor.
Although it was just the epidermis, which was in contact with the tumor.
In the case of grade II and III, this was always the case, whereas in STS I 36% of skin was infiltrated.
Which tumor attributes were included in a newly proposed grading system for feline STS?
Did the tumor grade correlate with survival?
(Dobromylskyj, JFSM, 2021)
It was MI, degree of necrosis and inflammation (instead of differentiation).
The tumor grades were associated with MST.
Garde I: 900 days
Grade II: 514 days
Grade III: 283 days
What was the response rate in dogs with STS that recieved SBRT?
How did it compare to palliative macroscopic RT or marginal surgery+ conventional fractionation?
(Gagnon, JAVMA, 2020)
Response rate was 46% (36% PR and 11% CR)- PFS 521 days, OS 2 years
It is better than palliative (PFI 5-14 months, MST 10-17 months)
worse than marginal excision+RT (DFI 3 years, OS > 5 years)
might be for dogs with inoperable tumors or where owners decline surgery
surgery post SBRT should be consiederd as well
Exploring OCT in STS tissue depth analysis what results were observed?
(Lages, VCO, 2021)
Low median tissue depth and neovasculirazation (50%) typical for STS
Itermediate median tissue depth and white lines for muscle
Greatest median tissue depth adipose tissue
-due to overleps between tissues, it should be evaluted with other OCT characteristics
What are the different patterns described by OCT for different tissues?
(Selmic, VCO, 2018)
Adipose tissue-low scattering, honeycomb texture pattern
Sarcoma-dense, highly scattering, not clearly recognizable structure
Muscle-dense, highly scattering, clear fibre alignment pattern
Which IHC staining should be used to identify Rhabdomyosarcomas?
(Touhy, Vet Pathol, 2021)
MyoDI, myogenin and desmin (as desmin is not always positive in RMS, it can lead to false negative diagnosis)
In a recent study evaluatig non-urinary Rhandomyosarcomas in dogs, which protein was expressed in almost all of the samples?
What were the findings of that study?
(Connell, VCO, 2020)
Ezrin, cytoskeleton linker protein associated with metastasis
median age 2 years, most tumors retrobulbar, orbital and subcutaneously
16/25 had metastatic disease at presentation, 3 dogs with diffuse disease
in 30% cases the cells looked like a round cell tumor—> IHC needed
MST was 10 days
What was the accuracy and sensitivity of deep learning enhanced OCT in dogs with STS?
(Ye, VCO, 2021)
accuracy 97%
sensitivity 94%
What was the prevalence of lung metastases in dogs with STS at presentation?
(Villedieu, JAVMA, 2021)
Grade 1: 6%
Grade 2: 6%
Grade 3: 38%
The odds of having metastasis <3 months after diagnosis was significantly lower than >3 months
Pulmonary staging is low yield in dogs with STS grade 1 and 2, present < 3 months
How was the inter- and intra-rater reliability and agreement in determining sc. margins in dogs with STS?
Ranganathan, VCO, 2018)
The inter- and intrarater reliability was good and excellent.
But the inter- (15-55mm) and intrarater (11-28 mm) agreement was unacceptable.
Veterinarinas may have difficulties determining the gross edge of the tumors, this can lead to bias in staging and outcome response.
