Perianal, AGASACA Flashcards
What was the accuracy of the algorithm develped to differentiate perineal adenomas from adenocarcinomas cytologically?
(Sabattini, JSAP, 2019)
87% (sensitivity 90%, specificity 85%)
However it needs further validation.
What is the most common clinical sign in cats with AGASACA?
Amsellem, JAVMA, 2019
Perineal ulceration and discharge
benign anal gland disease less common in cats, if symptoms occur, it should be further examined
What were the major risk factors for cats with AGASACA?
Amsellem, JAVMA; 2019
Recurrence and high nuclear pleomorphic score (histo).
When did recurrence occur?
What was the MST of cats with AGASACA?
(Amsellam, JAVMA, 2019)
recurrence occured median 96 days after surgery
MST was 260 days
-cats tolerated more aggressive surgery (pull through technic) well, without incontinence
-the role of chemo or radiation is unknown (4cats develpoed metastatic disease)
If dogs develop local recurrence or subsequent nodal metastatic disease or nodal recurrece in AGASACA is another surgery an option?
(Barnes, JSAP, 2017)
Yes, MST after the recurrence was 283 days.
What is optical coherence tomography (OCT)? Was it evaluated in AGASACA?
What is the purpuse of OCT?
(Dornbusch, VCO, 2020)
OCT is a high-resolution depth-resolved optical imaging technology that mimcs low magnification microscopic evaluation on histological slides. It can be used for the evaluation tumor margins.
It looks similar to an ultrasound, but uses infrared light waves instead.
It can image tissues up to 2mm in depth.
Images are created based on the cellular density and organisation.
OCT could identify the presence of tumor cells at or within 1 mm of margins of interest.
What is the clinical staging proposed by Polton and Brearley (2007)?
Stage I: T <2,5 cm without LN or DM Stage II: T >2,5 cm, without LN or DM Stage IIIa: any T, LN < 4,5 cm, no DM Stage IIIb: any T, LN > 4,5 cm, no DM Stage IV: any T, any LN, DM present
Why is the staging proposed by Polton and Brearley not widely accepted?
What was the MST of dogs with stage IV AGASACA treated with Palladia?
What was the clinical benefit of the treatment?
(Elliott, JAVMA, 2019)
The MST was 356 days, which is considerably longer than with non-TKI treatment (2-3 months).
No dog had CR, or PR, but 13/15 had SD.
Was the use of Palladia as primary or adjuvnt medication in AGASACA positive or negative prognostic factor?
What was the PFI and OST of these dogs?
(Heaton, JVIM, 2020)
It is a positive prognostic factor. There was a clinical benefit from ca. 80% (20% PR, 60%SD).
In the microscopic setting the usage of palladia was limitied, no conclusive evidence.
The PFI 313 days, MST 827 days.
What other type of tumor can occur in the anal sac of cats?
Is a multimodal therapy indicated?
(Kopke, JSAP, 2020)
SCC (2 cats)
Multimodal therapy 552 vs. therapy with NSAID 28 days.
Does the method of injection techique with lymphoscintigraphy influence on the identification of SLN in dogs with AGASCA?
(Linden, VRU, 2018)
Yes, intramural injection technique is superior than the peritumoral 4 quandrant.
The concordance between the 2 techniques was 50%.
To better asses the size of the primary AGASACA tumor which measuring techniqies were compared in a recent study?
(Schlag, JSAP, 2020)
Rectal examination, CT (glod standard) and formalin-fixed tissue.
Which factors were associatied with the presence of metastatic diesase when the different meaurment techniques were compared?
What was the agreement between the 3 techniqes? Is any of them superior?
(Schlag, JSAP, 2020)
T2 stage (>2,5 cm) measured with any technique and vascular invasion were assoc. with metastsis. MI was not. The agreemnet was moderate, no one technique is superior.
Which histological features were associated and not associated with poorer outcome in an AGASACA study?
(Pradel, VCO, 2018)
Not associated: MI
Associated: solid growth pattern, marked or moderate peripheral infiltration, lymphovascular invasion and necrosis
