Structure and Organization of Nucleic Acids Flashcards

1
Q

categories of noncoding DNA sequences

A

spacer sequences
introns
genes encoding nonprotein -coding RNAs
repetition DNA sequecnes

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2
Q

introns

A

noncoding sequences within genes

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3
Q

what is the most aundant class of noncoding sequences

A

repeitious DNA

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4
Q

satellite DNA

A

indentical repeasts of short sequences

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5
Q

how are satellite DNA repeats arranged

A

long, tandom arrays

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6
Q

organization of satellite DNA is important in what

A

gives DNA sequence a defined moleculate weight

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7
Q

where is most satellite DNA found

A

centromere and telomere

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8
Q

what is the most abundant class of repetitious DNA

A

interspersed repeats

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9
Q

exons

A

sequences that are translated into proteins

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10
Q

characteristics of genes in eukaryotes

A

discontinuous and consist of exons and introns

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11
Q

gene families arise form waht

A

gene duplication events

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12
Q

what are the similiaries between genes within a gene family

A

simliar nucleotide sequences and encode similiar proteins

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13
Q

pseudogene

A

when you have a duplicate gene that gets mutated adn inactivated

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14
Q

what is unique about a duplicate copy of a gene

A

it’s expendable and axxumulates mutations over time

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15
Q

chromatine

A

nuclear DNA that’s extensively associated with proteins

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16
Q

nucleosome

A

histone with DNA wrapped around them

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17
Q

homologous chromones

A

materal and paternal versions of same chromsome are similiar but not identifcal

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18
Q

how is mitochondrial genome different from nuclear genome

A

it’s circular
it’s poresent in mulitiple copies per organelle
high gene density
not extensively associated with proteins

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19
Q

what is the principal feature that sets eukaryotes apart from prokaryotes

A

nucleus

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20
Q

heterochromatin

A

intensely stain, compelxed with proteins, highly condensed and transcriptionally inactive

21
Q

where is heterochromatin found

A

periphery of nucleus

22
Q

euchromatin

A

translucent, contains transciriptionally active, decondensed DNA

23
Q

nucleolus

A

large, intesnly stained area that contains genes encoding ribosomal RNA

24
Q

what are chromosomes attached to

A

nuclear matrix

25
what are chromomsomal territories serprated by
interchromosomal domains
26
nuclear lamina
meshwork of filaments that astabilize the nuclear envelope on the inner surface
27
nuclear pore function
regulate traffic between nucleus and cytoplasm
28
what are teh 3 main types of large molcules that much be actively and selectively transported between nucleus and cytoplasm
mRNA proteins ribosomal subinits
29
what import protein helps with import of molecules into the nucleus
importin
30
what small GTP bindign protein mediates nucleu export
Ran
31
the majority of mRNA molecules are exported from the nucleus via what
ran-independent mechanism
32
what protein associated with the cytoplasmic face of nuclear pore complex and helps provide energy input needed for transport
Dbp5
33
what type of replication is DNA
semi-convservative
34
how are replication origins activated
in clusters
35
replication is _______ from each orgiin
bidirectional
36
how are nucleosomes replicated
existing histones are recycled whilst an equal numver of new histones are syntheized
37
what do you call enzymes that syntheisze DNA
DNA polyermases
38
all DNA polymerases are what
template directed
39
what is requried for DNA replication
primer
40
wha ter primers made from
RNA
41
how are RNA primers degrated
exonuclease
42
polymerases synthesize DNA in what direction
5' -> 3'
43
the newly synthesized DNA straing is _____ to the template strand
antiparallel
44
what are the nucletide donors for DNA synthesis
dATP, dGTP, dCTp, dTTP
45
what is released as each nucletoide is incoroprated
pyrophosphate
46
hydrolysis of pyrophossphate does waht
drices reaction to the right
47
how are origins of replication marked
oriin recognition compelx
48
waht DNA sequence is at telomeres
TTAGGG