Population Genetics Flashcards

1
Q

polymorphic

A

allele varient that is present in more than 1 percent of the popluation

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2
Q

highly polymorphic genes determine what

A

individual charactersitics

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3
Q

nonpolymorphic genes do waht

A

code for proetins with essential celluarl fucntiosn

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4
Q

every human is expected to carry how many deleterious recessive muations

A

3

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5
Q

how many nucleotide polymorphisms are between unrelated humans

A

6 million

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6
Q

what percentage of the world=s polymorphisma re found within any given popluation

A

90%

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7
Q

idea population has what characteriscs

A

large popluation size
equal fitness of offspring
random mating
no mutation or migration

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8
Q

genetic drift

A

small population

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9
Q

why does eugenics not work

A

the vast majority of mutant alleles are found in heterozygeotes, serving as a large reservoir for the trast
preenting reproduction of heterozygote carriers for recessive diseas will prevent reproduction altoghetr (since we all ahve detrimental alleles)

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10
Q

What does CF protect hyterozygotes agaisnt

A

typhoid fever

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11
Q

what population is most affected by CF

A

uropean

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12
Q

what does beta thalassemia protect heterozygotes agaisnt

A

malaria

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13
Q

what population is most affected by beta thalassemia

A

mediterranean

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14
Q

what does HFE protect heterozygotes agaisnt

A

plague

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15
Q

what population is most affected y HFE

A

european

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16
Q

old order amish of lancaster county has high prevalence of what

A

ellis van creveld

17
Q

french candians have a high prevence of what

A

tyrosinemia

18
Q

genome wide association studies

A

millions of SNPs are analyzed to compare the prevalence of certain SNPs in pateints to their prevalence in control cases.

19
Q

linkage

A

meitoic recombination between the two markers is somewaht unlikely and 2 markers will likely be inherted togeether

20
Q

why are small popluaotions used in studies of gene linkage

A

only a few genes contribute to disease

little heterogeneity in the disease