Stress (Paper 3) Flashcards
What is stress
- A state of physiological or psychological strain caused by things that tend to disturb functioning of the body
- A mismatch between demands made upon an individual and their ability to meet these demands
Physiology of stress
-Stress defined as the body’s reaction to an event (known as a stressor) that requires physical, mental or emotional adjustment or response
-A little bit of pressure can be productive, give you motivation and help you to perform better at something. However, excessive pressure can be unhealthy for the mind and body, leading to long term illness
-Anxiety and depression caused by stress
SAM pathway
-When the body perceives a situation as stressful the following chain of physiological chain of events is triggered in the bodies autonomic nervous system.
-The sympathomedullary (SAM) pathways generally deals with the short terms effects of stress
-Hypothalamus activates sympathetic branch of autonomic nervous system, causing adrenal medulla to release adrenaline
-Prepare body for fight or flight leading to increase in heart beat, blood pressure, breathing rate and inhibit digestion
PAS system
-In response to a stressful situation the hypothalamus activates the pituitary gland, which causes ACTH (adrenocorticotropic hormone) to be released, which stimulates the adrenal cortex to release corticosteroids, such as cortisol.
-These stress hormones have a number of functions they cause the liver to increase the release of glucose and suppress the immune system and control swelling after injury.
-After a few minutes the parasympathetic branch of the ANS will start to work and the adrenal medulla will release noradrenaline. This will reduce the “flight or fight” response and bring the body back too normal
Cortisol
-Hypothalamus and pituitary gland both located in brain, sense if blood contains right amount of cortisol
-If to low brain adjusts amount of hormones it makes, adrenal gland picks up on these and decides how much cortisol needs to be released
Cortisol receptors
-Cells in body receive and use cortisol in different ways, needs differ day to day
-When body is on high alert cortisol can alter or shut down functions that get in the way
-Could include digestive or immune system
-Sometimes cortisol levels can get out of control
Role of cortisol
-Cortisol constricts blood vessels and increases blood pressure to enhance the delivery of oxygenated blood
-This is an advantage for fight or flight situations but over time can lead to vessel damage which leads to cardiovascular disorders
-Cortisol helps regulate a persons stress levels
-When chronic stress is experienced cortisol remains high because threat of stressor stays
-Cushing’s syndrome is a disorder that occurs when your body makes too much of the hormone cortisol over a long period of time. Cortisol is sometimes called the “stress hormone” because it helps your body respond to stress
-If a person is constantly stressed then they are going to be releasing cortisol more often therefore affecting their cardiovascular system
Newcomer et al (1999)
-Found Ps given levels of cortisol high enough to produce blood sugar levels similar to those experiencing major stress events, were poorer at recalling prose passages compared with Ps given smaller amount
-Suggests high levels do impact on cognitive functions
-Vgnotzas et al (2013) found chronic insomniacs had increased PAS system leading to high levels of ACTH and cortisol
General adaption syndrome (GAS)
-One of the most influential pieces of research into physiology of stress ie how body responds to stressful situations was developed by Hans Selye
-Based on his work with rats, and later humans
-Rats in his research would become ill (stomach ulcers) even when given harmless injections
-Became ill from stress and humans would react same way
Selye’s 3 stages of GAS
- Alarm reaction
- Resistance
- Exhaustion
- Alarm reaction
-During initial alarm stage, perceived threats trigger hypothalamus to produce releasing hormone (CRF)
-Stimulate pituitary glands production of ACTH via bloodstream, then acts on adrenal cortex producing corticosteroids
-This happens paralel to adrenaline being released to prepare body for fight or flight
- Resistance
-During resistance stage, body’s resources fully mobilised to cope with the stressor
- Exhaustion
-If stressors persist and cannot be overcome, the resistance of the individual sooner or later gives way to exhaustion
-The physiological consequences include effects on adrenal glands (enlarged and depleted), endocrine system usually thrown into disarray
-Selye argued all body tissues and processes can be affected, and in extreme cases, become diseased
Evaluation of Selyes GAS
Strengths
-Seyle research was experimental therefore objective measure is possible and is supported by a lot of scientific research
Limitations
-GAS ignores the individual differences that characterise humans, e.g. gender, personality, and differences in physiological reactivity: The GAS suggests a universal response to stress
-Certain bacteria have been found to be the cause of ulcers. It could still be the case that stress weakens the immune system making ulcers more likely. Therefore not a direct cause but correlation
Stress and illness
Stress can have a serious affect on the immune system, thus leading to stress related illness
Immunosuppression
-Although short term stress is not dangerous, the effects of long term stress on the immune system can leave the body vulnerable to infection and disease, such as infections
-Studies have shown that the immune system is not affected in the same way by all stressors
-Only chronic stressors (eg berievment, marital disharmony or serious problems at work etc) tend to result in immunosuppression
Process of stress and immunosupression
-Stress leads to suppression of the immune system due to the action of the cortisol one of the corticosteroids (released as part of the stress response) as they suppress leukocyte activity and stops the production of the white blood cells, specifically T cells
-Sustained production of cortisol reduces immune function
-Interferes with activity of white blood cells (leukocytes) rescued ability to fight infection
-Stress linked to cardiovascular disorders (heart problems, high blood pressure), infections or cancer
2 types of lymphocytes
B cells- Produce antibodies which are released into the fluid surrounding the body’s cells to destroy the invading viruses and bacteria
T cells- if the invader gets inside a cell, the T cells lock onto infected cell, multiply and destroy it
Natural immunity
Body’s basic defence system made up of white blood cells, called leukocytes and natural killer cells. Help prevent illness by fighting and absorbing invading pathogens such as viruses and bacteria
Specific immunity
-More complex system made up of cells called lymphocytes
-Recognise invading pathogens and produce specific antibodies to deal with them
-Divided into cellular and humoral immunity
Celluar immunity
-Number of different lymphocyte T cells, natural killer, memory and helper T cells work together to attack intracellular (within cells) pathogens such as viruses
Humoral immunity
-Use lymphocyte B cells
-B cells work together to attack extracellular (outside cells) oathogens such as bacteria and parasites
-Form in bone marrow
Kiecolt glaser et al study on: slowing of wound healing due to immunosuppression
Aim: test hypothesis that psychological stress can cause damage to the immune system
Procedure:
-Natural exp, 26 participants recruited using advertisement
-Group 1, 13 women aged between 47-81 looking after relative with Alzheimer’s
-Group 2, control group 13 women matched with carer on basis of age and income
-Small wound made on each P and given stress scale to see how stressed they felt (self report)
-Chemical substance involved in stress also taken from each P
-Both tests indicated that the experimental group showed higher levels of stress than the control group
-Time taken for wound to heal was assessed by photographing wound regularly
Results:
-Found that time taken for wound to heal was significantly longer for carers in exp group (48.7 days) than control group (39.3 days)
-Carers also had a larger wound size
Conclusion:
-Results suggest stress does have an impact on immunosuppression
-Correlation not causation
-Only conducted on women, alpha bias
- Role of stress in illness, reference to cardiovascular disorders
-Cardiovascular= heart and blood vessels
-Blood pressure increases due to ‘fight or flight response’ of ANS
-Raised blood pressure and increase heart rate can damage blood vessels because blood is being pumped faster and so at a higher pressure through vessels
-Arteries become scarred, hardened and less elastic. My be unable to supply amount of blood organs need
Acute stress and chronic stress leads to:
-High BP
-CHD
-Stroke
-Can also be linked to smoking and diet
Arteriosclerosis
-Hardening of arteries with increased sugar production and the fact that stress response stops digestion speed up clogging of arteries
-If one vessel becomes completely closed off, the heart muscle is damaged. Heart attack occurs
Williams et al: study on cardiovascular
Aim: see if anger was linked to heart disease
Method:
-Gave questionnaire to 13,000 ppl, whereby none of them had heart disease
-Questionnaire contained a 10 question anger scale, for example if they felt like hitting someone when they got angry
Results:
-After 6 years health status of participants was checked. 256 had developed heart attacks. Those who scored highly on anger scale were two and a half times more likely to have had a heart attack than those with low anger scores.
-Ppl who scored moderately were 35% more likely to experience some sort of heart problems
Conclusion:
-The physiological response in stress is closely associated with cardiovascular disorders. It’s correlational evidence so causation cannot be assumed
Stress and cardiovascular: evaluation
-Stress increases risk of cardiovascular disease, not a direct causal factor
-Stress effects clearest with pre existing CHD, if you have CHD stress likely to make it worst
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Sources of stress and measuring stress: life changes and self report scales
-Throughout our lives, we all experienced life changing events, death of close on or getting married etc
-May cause stress and illness, can be positive or negative
Social readjustment ratings scale: Holmes and Rahe (1967)
-From their work in hospitals found many patients with heart disease reported life events in last year
-Used records of 5000 patients and created list of 43 events and 400 ppl to rate them, rated the psychological impact that would be required
-Each event given impact value as LCU
-Death or spouse given 100 LCU whereas minor violation of law given 11 LCU
-All events experienced in last year added up
SRRS: Results
-A score of under 150 increases chance of stress related illness by 30%
-Score of over 300 is a major crisis and increases the risk to 80%