STIs Flashcards

1
Q

symptoms of urethritis (ngonorrheae, ctrachomatis)

A

dysuria
frequency
purulent or mucopurulent discharge
minimal or asymptomatic

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2
Q

symptoms of cervicitis (ngonoorheae, ctrachomatis)

A

purulent discharge
endocervical bleeding
asymptomatic

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3
Q

symptoms of genital ulcer disease

A

ulcer on genitalia

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4
Q

prostatitis (prostate gland infection) symptoms

A

dysuria
bloody urine
lower back pain
pain testes/penis

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5
Q

what is pelvic inflammatory disease

A

ascending spread of pathogens from vagina to upper female genital tract

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6
Q

symptoms of PID

A
abd/pelvic pain 
cervical motion tenderness
vaginal discharge 
fever
elevated WBC 
intermenstrual bleeding
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7
Q

define serology

A

measures/detects antibodies to pathogen

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8
Q

most common STIs

A

gonorrhea
chlamydia
syphilis
trichmoniasis

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9
Q

which STIs are reportable to MB health

A
gonorrhea
chlamydia
syphilis 
hep b 
hep c
HIV
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10
Q

people wiht gonorrhea may be co infected with

A

chlamydia

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11
Q

NAAT

A

nucleic acid amplification test PCR detects specific DNA sequence of pathogen

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12
Q

DFA

A

diract fluorescent antigen

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13
Q

serology

A

measures/detects antibodies to pathogen

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14
Q

patients with syphillis may be coinfected with what

A

HIV

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15
Q

name some risk factors for stis

A
unprotected sex
MSM
age
geographic 
sex worker
gender
unaware
anonymous sex
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16
Q

some impact of stis

A
complications
PID
dmage to reporductive tract
transmission
antibiotic resistance
economic
congenital infections
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17
Q

which is the only sti greater in males

A

syphilis

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18
Q

sti patient education

A
risks of untreated infection/reinfection
abstain from sex 3 days after treatment 
barrier protection 
return to care if symptoms not improved
get tested
reduce risks of sexual activity
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19
Q

most common infection of gon

A

urethrutus

cervicitis

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20
Q

other tyoes of gon infection

A

oropharyanx
ocular
diffeminated gonococcal infection
neonatal conjunctivitis

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21
Q

incubation of gon

A

1-14 day

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22
Q

male symptoms of gon

A

symptomatic common
urethral - dysuria, frequency
anorectal - pain
pharyngeal - pharyngitis

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23
Q

female symptoms of gon

A

asymptomatic or min symptomatic
urethral: dysuria, frequency
anorectal pain
pharyngeal- pharyngitis

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24
Q

signs of gon

A

urethral, rectal, or vaginal discharge

adnormal vag discharge or uterine bleeding

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25
Q

male complications of gon

A
epidiymitis 
prostatitis 
urethral stricture
inguinal lymphadenopathy 
DGI
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26
Q

female complication of gon

A

PID
ectopic pregnancy
infertility

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27
Q

what is disseminated gon infection

A

ngon bacteremia seeds sites outside reproductive tract
fever, chills, joint pain, skin rash
if go to other organs ex. meningitis

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28
Q

symptoms of neonatal conjunctivitis

A

infection may lead to blindness

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29
Q

prevention of neonatal conjunctivits

A

erythromycin 0.5% eye ointment applied to newborns as prophylaxis

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30
Q

labs for gon

A

gram stain - gram negative diplococci
culture
NAAT

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31
Q

major concern for gon

A

antibiotic resistance

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32
Q

which antibiotics is gon completely resistant to

A

penicillin
ampicillin
fluoroquinolones - only use if local resistance <5%

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33
Q

what do you also treat for in gon

A

chlamydia due to high rate of concomitant infection

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34
Q

treatment of uncomplicated gon

A

ceftriaxone and azithromycin single dose

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35
Q

alternative treatment for uncomplicated gon

A

azithromycin single dose

cefixime and azithro

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36
Q

what should you do when monotherapy with azithromycin is use

A

test of cure

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37
Q

anogenital infection gon infection in <9yoa

A

cefixime and azithromycin
ceftriaxone and azithro
no alternative

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38
Q

pharyngeal infection treatment for <9yoa

A

ceftriaxone and azithro

alternative: cefixime and azithro

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39
Q

why dont we use macrolide in children under 1 month

A

pyloric stenosis

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40
Q

treatment of gon opthalmia and disseminated infection

A

ceftriaxone and azithro

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41
Q

what gon infections require hospitalization

A

meningitis and disseminated

any disseminated infection if under 9

42
Q

treatment for ophthalmia neonatorum

A

ceftriaxone
irrigate eyes hourly
test for chlamydia (no prophylaxis)
hospitalization and consult with expert

43
Q

anogenital gon alternative treatment if contraindication to cephalosporins and macrolide resistance

A

gentimicin iv or im plus azithromycin or doxy

44
Q

when should you repeat screening in someone with a gon infection

A

6months after treatment

45
Q

when do you test for cure for ngon

A
pharyngeal infections
presistant symptoms
alternative treatment 
reexposure
pregnancy 
disseminated
child 
abortion 
AM resistant
46
Q

symptoms of PID

A

lower ab pain
irregular menstrual bleeding
fever
pain with intercourse and urination

47
Q

complications of PID

A

tuboovaria abscess
infertility
extopic pregnancy
chronic pelvic pain

48
Q

chlamydia pathogen

A

gram negative obligate intracellular pathogen

49
Q

chlamydia incubation

A

35 days

50
Q

chlamydia onset

A

7-21 days

51
Q

sites of chlamydia infection

A
endocervical canal 
urethra
oropharynx
rectum 
eye
52
Q

chlamydia sigs in symptoms in men

A
often asymptomatic
dysuria 
discharge 
pharyngitis
rectal pain discharge bleeding
53
Q

chlamydia signs and symptoms in women

A

subclinical
pharyngitis
discharge
uterine bleeding

54
Q

male complications of chlamydia

A

epididymitis

reiters syndrome

55
Q

female complications of chlamydia

A

PID
ectopic pregnancy
infertility
reiters

56
Q

newborn exposure to chlamydia can result in

A

neonatal conjunctivitis

pneumonia

57
Q

diagnosis of chlamydia

A

NAAT
DFA
culture if treatment failure
symptoms and history

58
Q

treatment options for uncomplicated urethral endocervical rectal and conjunctival infections in >9yoa

A

azithromycin one dose

doxy 7 days

59
Q

treatment option for chlamydia in children

A

azithro

erythromycin

60
Q

treatment option for chlamydia in pregnant women

A

azithro - weigh risk ad benefit
erythro
amox if cant tolerate either

61
Q

pathogen in syphilis

A

treponema pallidum spirochete

invades humans only through mucous membranes or open lesions

62
Q

co infection of syphilis and ____ is common

A

HIV

consult with specialist

63
Q

describe primary syphiliis

A

genitalia, perianal, mouth, throat
chancre, regional lymphadenopathy
incubation 3 weeks

64
Q

describe secondary syphilis

A

multisystem
rash, fever, malaise, mucous lesions, alopecia, meningitis..
incubation 2-12 weeks

65
Q

describe latent syphilis

A

multisystem dormant

asymptomatic

66
Q

describe tertiary syphilis

A

cardiovascular - aortic aneurysm, coronary artery stenosis, 10-30years
neurosyphilis - vertigo, personality changes, 2-20 years
gumma - tissue destruction of any organ, 15 years

67
Q

syphilis in newborns

A

tpallidum can cross placenta, highest risk when mom in primary/secondary
screen for signs of early congenital syphilis

68
Q

diagnosis of syphilis

A

history and cliinical presentation
dark field microscopy
NAAT
serologic - treponemal, non treponemal

69
Q

treatment of primary, secondary, and early latent <1 yr duration syphilis

A

benzathine penicillin IM single dose
alternative: doxycycline PO 14 days
ceftriaxone IV 10 days

70
Q

treatment of late latent or unknow duration latent and tertiary (not involving CNS) syphilis

A

benzathine penicillin IM 3 doses

alternative: penicillin desensitization, doxy for 28 days, ceftriaxone IV for 10 days

71
Q

treatment of neurosyphilis

A

pen G x10-14 days

alternative: penicillin desensitization followed by penicillin, ceftriaxone IV x 10-14d

72
Q

treatment of sexual contacts in prior 90 days to syphilis

A

pen G single dose IM

73
Q

treatment of syphilis in pregnant women

A

pen G IM

consider pen desensitization followed by treatment with pen

74
Q

trichomonas pathogen

A

trichomonas vaginalis
flagellated motile protozoan
humans only host

75
Q

incubation time for trichmonas

A

3-28 days

detectable 48hr after exposure

76
Q

sites of trichomonas infection

A
urethra
endocervical canal 
rectum 
oropharynx
eye
77
Q

signs and symptoms of trichomonas in males

A

asymptomatic (more common than in females)
urethral discharge
dysuria, pruritis

78
Q

signs and symptoms of trichomonas in women

A
asymptomatic 
malodorous vag discharge and pruiritis 
dysuria, dyspareunia 
vag ph 4.5-6 
inflammation of vulva/vagina/cervix 
urethritis
79
Q

male complication of trichomonas

A

epididymitis and chronic prostatitis

male infertility

80
Q

female complications in trichomonas

A

PID
premature labor
premature rupture of membranes, low birth weight infants
cervical neoplasia

81
Q

diagnosis of trichomonas

A

history
presentation
NAAT
microscopy

82
Q

treatment of trichomonas

A

metronidazole single dose of 7 days
intravaginal metronidazole is not effective
metronidazole not CI in pregnancy or breast feeding

83
Q

efficacy of trichamonas treatment

A

88% increase to 95% if partner also treated

84
Q

infection sites of HPV

A

moist mucose of anogenital tract, oral cavity and oropharynx

non mucosal causes warts on hands and feet k

85
Q

describe hov type 6 and 11

A

low risk

cause anogenital warts

86
Q

describe HPV 16 and 18

A

high risk

cause cervical cancer

87
Q

prevention of HPV

A

condoms
counselling
screening
HOV vaccination

88
Q

describe gardisal

A

approved for females 9-45 and males 9-26

3 doses at 0,2,6 months

89
Q

describe gardisil 9

A

4 HPV types added

90
Q

describe ceravix

A

used for females 9-45

3 doses at 0, 1, 6 months

91
Q

treatment of HPV

A

see specialist

92
Q

difference between HSV 1 and 2

A

1 - oropharyngeal and genital disease

2- genital disease

93
Q

5 stages of HPVinfection

A
primary mucocutaneous 
ganglia 
latency 
reactivation 
recurrent infection
94
Q

difference between 1st episode primary and non primary

A

primary - HSV antibody negative individual

non primary - HSV + antibody, prior exposure

95
Q

diagnosis of HSVC

A
history 
presentation 
electron microscopy 
tissue culture 
NAAT 
immunoflourescence assay
96
Q

treatment of HSV

A

no cure
antivirals acyclovir, famciclovir, valacyclovir modify course
first episode antiviral reduce shedding and duration
recurrent can treat when prodrome or continuously suppressive to reduce frequency

97
Q

HSV incubation

A

2-14 days

98
Q

1st episode of HSV signs and symptoms

A

usualy asymptomatic
multiple painful lesions of external genitalia develop in a week and heal in 2-4 weeks
flu like symptoms
itching, pain, discomfort, discharge

99
Q

how long does shedding of HSV occur for

A

primary 11-12 days, nonprimary 7 days

recurrent 4 days

100
Q

in which people are HSV symptoms more severe

A

females
IC
primary infection

101
Q

sings and symptoms of recurrent HSV

A

prodrome - itching, burning, tingling
fewer lesions, milder
asymptomatic viral shedding during first year of infection

102
Q

complications of HSV

A
secondary infection of lesions
extragenital infection because of autoinoculation 
disseminated
meningitis 
encephalitis
neonatal transmission