Azole antifungals Flashcards
fluconazole spectrum
c albicans
NO C.KRUSEI
decreased glabrata
blastomyces
itraconazole spectrum
increased endemic- blastomyces, coccidioloides, paracoccidioiodes, histoplasma
aspergillus (molds)
calbicans not krusei
voriconazole spectrum
compared to fluconazole increase glabrata and krusei
asperigillus and fusarium (molds)
posaconazole spectrum
same as voriconazole (increased glabrata, krusei, and molds)
but also increase mucorales (molds)
fluconazole formulations and how to take
oral wiht food
iv
formulations and how to take for itraconazole
capsules take with food and things that decrease the pH
soltuion do not take with food
voriconazole formulations and hot to take
tablets without food
iv - cyclodex (CI in clcr<50)
posaconazole formulations and how to take
suspension give with fatty food
delay tablets give with food
iv - cyclodex (CI clcr<50)
which has polymorphic metabolism and can result in sig increase in concentrations in the slow metabolizers
also nonlinear kinetics
voriconazole
adverse effects in all azoles
GI
rash
hepatic
fluconazole adverse effects
alopecia - hair loss
itraconazole adverse effects
Gi due to cyclodex
hypertension
decrease potassium
edema
voriconazole adverse effects
alopecia rash QT altered vision photphobia hallucinations periostitis (inflammation of layer of tissue that surrounds the bone)
posaconazole adverse effects
reduced
echinocandin adverse effects
infusion site reactions headache fever chills hypokalemia decreased hemoglobin increased hepatic enzymes
