Fungal infections other

Question 1

characteristics of aspergillosis

Answer 1

spore forming mold

environemental exposure

Question 2

most commone aspergillosis

Answer 2

a.fumigatus

Question 3

presentations of aspergillosis

Answer 3

allergic aspergillus bronchopulmoitis or sinusitis 
cutaneous 
non invasive lung/sinus-fungus ball 
invasive mostly pulmonary 
disseminated

Question 4

most likely to be infected by aspergillosis

Answer 4

significantly IC

– hematologic malignency, transplants, prolonged neutropenia

Question 5

treatment of invasive aspergillosis

Answer 5

consider granulocyte stimulatin factor/infusions
voriconazole potentially with 2 week combo with echinocandin
ampho B allternative

Question 6

duration of invasive pulmonary aspergillosis therapy

Answer 6

> 6-12 weeks

Question 7

monitoring for voriconazole in invasive pulmonary aspergillosis

Answer 7

steady state concentrations after 4-7 days of 1-5.5ug/mL

assay not always available

Question 8

secondary prophylaxis for invasive pulmonary aspergillosis

Answer 8

vorixonazole or posaconazole during subsequent immunosuppresion
alternative:
itraconazole - unreliable BA
caspofungin/micafungin

Question 9

describe blastomyces

Answer 9

spore forming mold
environmental exposure
common in manitoba lake of the woods

Question 10

most common blastomycosis

Answer 10

b.dermatitiidis

Question 11

types of blastomycosis infections

Answer 11

acute or chronic pulmonary infection - involve skin, osteoarticular, genitourinary or CNS
disseminated 3-6mon post exposure

Question 12

treatment of blastomyces mod-sev

Answer 12

amphoB 1-2wks max 2g then itraconazole 200 q12hr x 6-12mon

Question 13

treatment of blastomycosis mild-mod

Answer 13

itraconazole 200 q12hr x 6-12mon

Question 14

mucormycosis is also spore forming mold from environmental exposure that i dont really care about it but what is the treatment

Answer 14

surgical treatment in conjunction with amphoB

alternative: posaconazole