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bmp > stimulants > Flashcards

stimulants Flashcards

1
Q

methylxanthines

A

naturally occurring alkaloids

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2
Q

caffeine ADME

A

oral absorption (30mins)
crosses BBB
crosses placenta
hepatic (CYP1A2)

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3
Q

caffeine MOA

A

adenosine receptor antagonist

adenosine = inhibitory NT

increase NT release

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4
Q

caffeine effects

A

increases alertness
vasoconstriction
inhibits allergic histamine release

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5
Q

caffeine dependence

A

withdrawal: headache, fatigue, impaired psychomotor performance, depression

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6
Q

caffeine use

A

headache

neonatal apnea

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7
Q

caffeine Rx interactions

A

quinolone ABX

inhibits metabolism of antipsychotics

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8
Q

amphetamine

A

50:50 d and l amphetamine

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9
Q

destroamphetamine

A

d amphetamine

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10
Q

methamphetamine

A

amphetamine + methyl group

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11
Q

amphetamine ADME

A

oral absorption (1-3hr)
crosses placenta
crosses BBB
hepatic metabolism

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12
Q

amphetamine MOA

A

release NE and DA through exchange diffusion

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13
Q

amphetamine effects

A

low dose: wakefulness
high dose: stereotypy
cardiac stimulation

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14
Q

amphetamine dependence

A

tolerance builds rapidly

withdrawal is not life threatening

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15
Q

amphetamine use

A

ADHD
narcolepsy

ineffective for long-term weight loss

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16
Q

amphetamine SE

A

chronic use: paranoid psychosis

arteritis obliterans

17
Q

amphetamine Rx interactions

A

MAO inhibitors

tricyclic antidepressants

18
Q

methylphenidate ADME

A

oral absorption (1-3hrs)
crosses placenta
hepatic metabolism

19
Q

methylphenidate MOA

A

blocks DA reuptake

20
Q

methylphenidate use

A

ADHD

narcolepsy

21
Q

methylphenidate SE

A

few CV effects

22
Q

methylphenidate Rx interactions

A

MAO inhibitors

tricyclic antidepressants

23
Q

methylphenidate BBB

A

chronic use leads to dependence
psychotic episodes can occur
withdrawal: severe depression

24
Q

atomoxetine MOA

A

blocks NE reuptake

25
Q

atomoxetine use

A

ADHD

26
Q

cocaine

A

natural plant alkaloid

27
Q

cocaine ADME

A

IV/smoking
initially goes to brain
redistributes throughout body
metabolized by plasma esterases

28
Q

cocaine MOA

A

blocks NE, DA, and 5HT reuptake

blocks Na+ channels

29
Q

cocaine effects

A

vasoconstriction

30
Q

cocaine dependence

A

psychological
physical
not life threatening

31
Q

cocaine use

A

local anesthetic

32
Q

cocaine SE

A 
OD: fatal
paranoid psychosis
arrhythmias, cardiac arrest
bowel ischemia
reduce fetal bloodflow

bmp (7 decks)

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