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bmp > antidepressants > Flashcards

antidepressants Flashcards

1
Q

tricyclic antidepressants (1st gen)

A

resemble phenothiazine antipsychotics

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2
Q

tricyclic antidepressant ADME

A 
first pass effect
lipid soluble
bound to plasma proteins
slow elimination
active metabolites
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3
Q

tricyclic antidepressant MOA

A

inhibit NE and 5HT reuptake
block muscarinic ACh receptors
block alpha1 NE receptors

2-3wk to start seeing effect
8-10wks for max effect

changes in neurogenesis

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4
Q

tricyclic antidepressant effects

A 
sedation
CNS depressants
promote sleep
mood elevation (may feel worse first)
high dose: seizure
antimuscarinic effects
arrhythmias
orthostatic hypotension
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5
Q

imipramine

A

tricyclic AD

bed-wetting

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6
Q

desipramine

A

tricyclic AD

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7
Q

amitryptyline

A

tricyclic AD

most commonly used

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8
Q

clomipramine

A

tricyclic AD

OCD

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9
Q

nortriptyline

A

tricyclic AD

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10
Q

tricyclic antidepressant SE

A 
orthostatic hypotension
arrhythmias
weight gain
withdrawal
OD: fatal
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11
Q

all antidepressant BBW

A

increase risk of suicidal thinking/behavior in children, adolescents, and young adults

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12
Q

tricyclic antidepressant Rx interactions

A

potentiate other CNS depressants
potentiate hypertensive effects
monoamine oxidase inhibitors
additive effects

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13
Q

mirtazapine

A

2nd gen AD

blocks 5HT2 and a2 adrenergic receptors

SE: weight gain

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14
Q

trazodone

A

2nd gen AD

inhibits 5HT uptake
blocks 5HT2 receptors

SE: priapism (hella big dick…stay away)

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15
Q

buproprion

A

2nd gen AD

weak inhibitor of reuptake

use: smoking cessation

SE: seizures

DONT GIVE IF SEIZURES OR EATING DISORDERS

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16
Q

Selective Serotonin Reuptake Inhibitor use

A

anxiety disorders

17
Q

SSRI SE

A 
nausea
GI upset
HA
insomnia
nervousness
sexual dysfunction
withdrawal
18
Q

fluoxetine

A

SSRI

19
Q

paroxetine

A

SSRI

20
Q

fluvoxamine

A

SSRI

21
Q

sertraline

A

SSRI

22
Q

citalopram

A

SSRI

23
Q

escitalopran

A

SSRI

24
Q

vilazodone

A

SSRI

inhibits 5HT reuptake
5HT1 receptor partial agonist

25
Q

vortioexetine

A

SSRI

inhibits 5HT reuptake
agonist/partial agonist/antagonist at different 5HT receptors

26
Q

Serotonin/Norepinephrine Reuptake Inhibitor use

A

anxiety disorders

27
Q

SNRI SE

A

hypertension

withdrawal

28
Q

Duloxetine

A

SNRI

chronic pain

29
Q

Venlafaxine

A

low dose: blocks 5HT reuptake
high dose: blocks 5HT and NE reuptake

SE: insomnia

30
Q

Desvenlafaxine

A

SNRI

31
Q

Levomilnacipran

A

SNRI

32
Q

Monoamine Oxidase Inhibitors Rx interactions

A

hypertensive crisis if sympathomimetic amines are given or tyramine ingested

stroke/death

potentiate tricyclic antidepressants, CNS depressants, opiates

33
Q

serotonin syndrome

A

MAO inhibitors and L-Trp interacts with SSRI’s causing excessive 5HT neurotransmission

AMS
seizures
coma

Tx: stop all serotonergic drugs

34
Q

mood stabilizers use

A

bipolar disorder

35
Q

lithium use

A

mania

mood stabilizer in bipolar disorder

36
Q

lithium effects

A

calms mania
dampens mood swings
leukocytosis

37
Q

lithium ADME

A

rapid absorption
not metabolized
renal excretion

38
Q

lithium SE

A 
low therapeutic index
fine tremor (Tx: propanolol)
thyroid enlargement
cardiac arrhythmias
inhibits ADH action
sodium retention
weight gain
39
Q

lithium Rx interactions

A

diuretics decrease renal clearance

bmp (7 decks)

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