benzodiazepines Flashcards
1
Q
benzodiazepines ADME
A
oral absorption crosses BBB crosses placenta oxidation > active metabolites conjugation > inactive metabolites
2
Q
lorazepam
A
IM absorption
inactive metabolite
3
Q
diazepam
A
active metabolite
long acting - accumulation
4
Q
chlordiazepoxide
A
active metabolite
long acting - accumulation
5
Q
clonzepam
A
active metabolite
long acting - accumulation
6
Q
midazolam
A
short halflife
use: conscious anesthesia, induction of anesthesia
7
Q
oxazepam
A
inactive metabolite
8
Q
temazepam
A
inactive metabolite
9
Q
benzodiazepine MOA
A
bind GABA-A receptors
increase frequency of channel opening
10
Q
benzodiazepine effects
A
antianxiety sedation sleep muscle relaxant anticonvulsant CNS depression not analgesic
11
Q
benzodiazepine dependence
A
psychological
physical
withdrawal/abstinence syndrome
12
Q
benzodiazepine use
A
anxiety sedation muscle relaxation seizure disorders ethanol withdrawal
13
Q
benzodiazepine SE
A
sedation confusional states in elderly anterograde amnesia can't drive OD: fatal (Tx: flumazenil)
14
Q
benzodiazepine Rx interactions
A
ethanol or CNS depressants
15
Q
buspirone
A
partial 5HT1 receptor agonist
