drug abuse

Question 1

dispositional tolerance

Answer 1

changes in pharmacokinetic properties of the drug

Question 2

pharmacodynamic tolerance

Answer 2

adaptive changes in affected systems

Question 3

behavioral tolerance

Answer 3

individual learns how to adapt or compensate in presence of the drug

Question 4

cross-tolerance

Answer 4

drugs with similar MOA

Question 5

physical dependence

Answer 5

drug is needed for homeostasis

withdrawal: abstinence syndrome

Question 6

psychological dependence

Answer 6

drug seeking behavior

Question 7

addiction (C’s)

Answer 7

compulsive use
lack of ability to control drug use
continued use in face of adverse consequences