STI Lesions Flashcards
HSV 2
__ and __
incubation time __ to __ d
CM: __ ulcers of __ or __
Bilateral painful ___
sometimes assc w __
urethral lesions can cause ___ leading to __
Depiction: __ on erythematous base that does not follow ___
Dx: rapid detection kits detect ___ to HSV glycoproteins __ and __
gold standard includes __ with DFA or ____
also __
dsDNA, enveloped
1-28d
painful, genitalia/anus
inguinal adenopathy
flu-like sx
retention, UTI
multiple vesicles, dermatomal distribution
antibodies, G1/G2
viral subtyping, NAAT
culture
Pathophys of HSV2
HSV replicates in __ and __ at site of infection
produces __ and causes __ of epidermis
virus spreads to __ that innvervate primary infection sites, establishing ___
Viral load is highest at ___
Asx viral shedding most common __ after present
Comps __ and __
subtype allows differentiation from __
skin/MM
infectious virions, vesicular lesions
sensory neurons, latency
primary infection
3-12mnths
HSV encephalitis, congenital defects
HSV1
Treponema pallidum aka
__ with __ shape
spreads via __ w infectious lesions or __, _ and __
Dx: __ and DFA from __/__ lesion
R or V
T pal enters via ___ of epithelial cell linings of __ and __
slowly multiply at ___, orgs enter ___ and __, infecting __ and __ and __ and __
syphillis
spirochete, corkscrew
contact, body fluid, in utero, transfusions
darkfield micro, 1/2 lesion
RPR, VDRL
tiny abrasions, MM/hair follicles
site of infection, bloodstream/lymphatics
skin/endo cells/neurons/MM
Primary syphillis
bacteria multiply at site of infection form ___
bacteria then carried via __ and __ to __ causing regional ___
Secondary syphillis
orgs carried through __ to __/__ cause __
Tertiary syphillis
orgs carried to __ and __ cause neuro sx
hard chancre
lymph/blood, LN, adenopathy
blood, skin/MM, lesions
neurons/brain
Primary syphillis
single __, indurated ___ at site of innoc
appears __w after infection
persists __w
caused by __ that multiply at site of infection
Men located at G/C/S/P
Women at: L/A
bilateral, nontender __/__ develops
painless, ulcer/chancre
3w
4-6w
treponemes
glans, corona, shaft, perianal
labia, anus
inguinal/regional adenopathy
Secondary syphillis \_\_ w after ulcer widespread \_\_ and \_\_ lesions esp on \_\_ other sx: M/A/H/S/A/ general \_\_
condyloma lata
moist, flat/raised lesion around __, patches of __ in mouth, __ and __ areas
lasts __w, then enters ___
can last for ___ as __ w no sx
Tertiary syph
Gummatous- __ lesions coalesce in __/__/__
Neurosyph: general __, T, A
4-10w
skin/MM
palms/soles
malaise, anorexia, HA, sore throat, arthralgia, LAD
perianal, mucosa, tongue, intertriginous
2-6w, latent stage
decades, seropositive
granulomatous, skin/bone/MM
paresis, TD, AR pupils
Haemophils ducreyi aka \_\_ streptobacilli \_\_ appearance incubation of \_\_days commonest in A/A/L
More common in __
Tender, painful __ on penis/vagina
can spread laterally to __/__
ulcer has __ covered w __/__ purulent exudate and shaggy __
can become ___
chancre may __ or __
chancroid gram - school of fish 1-21d asia, africa, LA
men
non-indurated ulcer
inner thighs/buttocks
friable base, gray/yellow, border
suppurative
resolve/persist
Dx Haemophilus ducreyi
assess __
gram stain of __ from LN/ulcer
fastidious on __, so __/__ provides quicker culture
H ducreyi enters through __, produces __/__ that ulcerates to form __
dense inflam __ w ___
bacteria trasnported to __ from site of infection
__ LAD
may lead to __ if severe
ulcer
aspirate
chocolate agar, serology/NAAT
skin abrasions, papule/vesicle, chancre
exudate w PMNs
LN
inguinal
inguinal buboes
HIV subtypes 6/11 aka __
__ and __ virus
CM: condylomata acuminata
cauliflower like __ lesions on skin, E, P, P, I regions
warts can be __, __, __
Dx w __, warts are not __, biopsy of __
HPV infects/replicates in ___ of skin/MM
6/11 induce __ to prolif
thickens ___ and __ forming verrucae (Warts)
genital warts
dsDNA, naked
exophytic
external genitalia, perineum, perianal, intra-anal
painful, friable, pruritic
CM, soft, wart
squamous epithelial cell
keratinocytes, stratum granulosum/spinosum
