Gonorrhea/Chalmydia Flashcards
If someone has __ or __, tx both
majority of individuals are __
Neisseria is __, w __ on outside
__ is antigen, __ for adhesion
__ leads away from UTI
also look for ___
N meningitidis is a __, whereas __ is not
Gonorrhea, chlamydia
asx
gram -, LPS
lipid A, pilli
vaginal discharge
ulceration
maltose fermenter, N gonorrhea
N gonorrhoeae
Gram negative ___
incubation time __ d
CM Men : U, P, P, E
__ discharge from __ or _ in MSM
CM women: many ___
__/__ discomfort, D/D
can get E/P following __ intercourse/spread from __
Dx men: __ from urine
___ of discharge
Dx women: __ swab, __ of discharge
diplococci
3-14d
urethritis, prostatitis, proctitis, epipdidymitis
mucopurulent, urethra/anus
asx
vaginal/pelvic, dysuria, discharge
Endocervicitis/proctitis, anal, vagina
PCR, culture
endocervical, culture
Tests show __ urine, negative __
urine dipstick positive for __
__ seen on urine micro
Hallmark is __ and diplococci located __ and __
Culture on __ agar- enrich for _ w lots of __
__ hrs to produce colonies
produces __
Comps: can ascend, leading to __ (ex in woman)
clear, urine culture
LE
multiple white cells
PMNs, extra/intracellular
Thayer Martin, NG, ab
36-48
CO2
PID
NG vertical transmission can result in gonococcal __
P/R/__ discharge
Virulence factors
Pilin binds __, essential for __, undergoes __ and __
__proteins to inc adherence to __, dtermines __ of organisms
__ protease, cleaving _ at hinge, lysing __
__proteins inhibit __ and __
bacteria adhere to __/__epi, __ induce uptake, bacteria pass through cell via __ and released at ___ into ___
go to ___ and __
conjunctivitis
pain/redness/purulent
CD46, adhesion, phase variation/antigenic variation
Opa, epiithelial cells, tissue tropism
IgA1, IgA1, lysosomal membranes
Porin, PMN maturation, respiratory burst
urethral/cervical, opa proteins, transcytosis, basolateral surface, subepithelial space
bloodstream, disseminate
Pili proteins have ___
promoter encodes for multiple __, leading to ___ pili proteins
means that __ and __ is difficult
disseminated gonorrhea presents w __ usually at
antigenic variation
loci, varied
tx, immunity
inflamed joints, knee
Chlamydia trachomantis serovirus D-K
__ bacterium, not seen on __
incubation time __
CM Men: most __, __ urethritis
may have __ if restricted to urethra
D, E (MCC)
possible __ discharge
CM women: most __, U w __ discharge
C__ w D, P, D, __ pain
can cause __ or __ w oral/anal sx
Dx: cutlure w __/__ very slow
use __ or __
obligate intracellular, gram stain
3-14d
asx, non-gonoccal
serous discharge
dysuria, epididymitis, white urethral
asx, urethritis, serous
cervicitis, dysuria/pyuria/discharge, lower ab pain
pharyngitis/proctitis
DFA/staining
NAAT/PCR
Clamydia trachomantis testing
use ___ to inoculate __ or __ cells
check for CT using ___ which appear red
or __ for iodine staining __
iodine stains __ in IB
specific bc other species of C do not contain __
endocervical swab, HeLa/McCoy
DFA
iodine staining, inclusion bodies
glycogen
glycogen
CT life cycle Elementary bodies are \_\_ metabolically \_\_\_ prevent fusion of \_\_ and \_\_ once in \_\_, transform to \_\_
Reticulate bodies
metabolically __
replicates in ___
convert back to __ prior to cell lysis
tissue damage results from host __ to infection and __ to infected cells by bacteria ___
__ and __ IS fail to eliminate bacteria
infection infiltrated w __, __, __
continues to prod __/__ resulting in __ due to __
infectious
inactive
endo/lysosome
endosome, RB
active
endosome
EB
HeLa, McCoy
inflam response, direct damage, cytotoxins
innate/adaptive
Macros/PC/eosinophils
cyto/chemokines, scarring/fibrosis
CT serovars L1-L3
Rare in __
persists in A/A/S/C
inc time __
single __ on penis, anus, VV area
2-6wks later, presents w F, M, painful unilateral __ inguinal LAD
can cause ___ and __/__ LAD if arises from rectum/cervix
bacteria not cleared from __ proceeding to infect __, causing ___
Dx w __, __ and __/__/__
Biovars infect __/__ passing to regional LN
US
asia, africa, SA, caribbean
3-30days
painless ulcer
fever, malaise, suppurative
proctocolitis, perirectal/deep iliac
infection, LN, inguinal buboe
CM, cytology, culture, NAAFT, DFA
monos/macros
lymphogranuloma venereum
Primary lesion: __ papule/ulcer on genitalia
inc time ___
Secondary lesion w __
__ dissemination causes __ LAD
may form suppurative __
LAD is usually __ in women and __ in men
Tertiary aka __ syndrome
develop ___ and __ resulting in chronic ___ or __, rectal __ and genital ___
painless
3-30d
LAD
regional, inguinal/femoral
buboe
retroperitoneal, inguinal
genito-ano-rectal
proctitis, fibrosis
genital ulcer/fistula, elephantiasis
Ureaplasma urealyticum and mycobacterium genitalium
___ mucosal pathogens in __
non ___/__ urethritis w no pathogen on __
__ colonies
UU has no __, CM made of __
UU metabolizes __ via urease
raises urine __, producing __ and __
Dx: ___ discharge assc w urethritis
non-invasive, healthy host
gonoccocal/chlamydial, culture
fried egg
cell wall, sterols
urea, pH, struvite stones/infections
non-purulent
PID sx
C T\_\_ A A V
cervical motion tenderness tender to palpation adnexal tenderness ab pain vaginal bleeding
