Androgen Pharm Flashcards
Peptide hormones
Hypothalamus releases
AP releases (3)
Synctiotrophoblast releases
Placenta releases
Developing testes releases M____ (3)
GnRH
FSH, LH, Prolactin
HcG
Placental lactogen
mullerian inhibitory factor
MIH, MIS, AMH
AMH/MIF leads to
Testes convert __ to ___
Testosterone needed for __
DHT needed for
Unilateral Mullerian duct regression leads to loss of ___/___, seen in ___
Wolfian duct regression bilateral leads to loss of ___/___, important for __
differentiation occurs around ___ wks
Mullerian duct regression
T to DHT
Wolffian/Ejac ducts
virilization of external genitalia
cloaca/Mullerian duct, males
cloaca/ Wollfian duct, females
8
FSH and LH act on __ and __ respectively
these inc ___ production, eventually forming __ via 5a reductase
Gonadal dysgenesis: appropriate sex differentiation requires coordinated actions of ___ and ___ and the conversion of __ to ___
Lack of MIH leads to __
With DHT pt is ___, lacking T leads to ____
+MIH, patient is __
with DHT is ___, without T is ___
sertoli/Leydig
Testosterone, DHT
MIH, Testosterone, T to DHT
Internal female
External male, external female
Internal male
External male
External female
5A reductase
Type 1 found in
KO Leads to ___ estrogen toxicity
eventually, __ demise and ___ defects
Type 2 found in ___
defic results in ___ at birth, usually ___
can be reversed at puberty as __ is converted by ____ resulting in male gender
Liver/skin
midgestation
fetal, parturition
urogenital tract/liver
ambiguous gender ID, female
T, type 1 5AR
Sex hormones Steroids E includes P includes Androgens include
Kd for Andogen receptors DHT ___< T
GnRH pulse generator drives ____ of FSH/LH
Gonadal steroidogenesis begins w ___
Estrone/Estradiol/Estriol
Progesterone, MPA
T, DHT
1000
pulsatile secretion
cholesterol
Androgen actions mediate ___
S
L
Possible M and A
as an anabolic steroid, inc in ____ and stimulates ____
Actions in sexually mature adult is ___
AR is ___ in normal males, anabolic actions require ___ suggesting cross talk w ___ or other receptors
male SSC
spermatogenesis
libido
male pattern behavior, adipocity
lean body ass, erythropoeisis
fxnally saturated, very high doses, GR
Inhibitors of androgen action is effective in tx of
H/C of prostate (__ dep)
A (__ dependent)
M (__ and __ dependent)
V (such as __ and __)
P (__ dependent)
Decrease ___ in sex offenders (__ dependent)
Testosterone binds __ or activated by ___ to DHT, which binds ___
___ occurs, affecting __ of T dependent genes
hyperplasia/carcinoma, DHT
Acne, T
male pattern baldness, T/DHT
Virilization in females, hirsutism/clitormegaly
PP in boys, T
sex drive, T
AR, 5AR, AR
Homodimerization, cell trxn
T criculates in the blood bound to __ or ___
only __ T diffuses through PM of cells
androgenic activity is much greater for ____
__ inhibits 5AR, can be used for ___ and ___
actions of steroid determined by ___ and ___
SHBG, albumin
free
DHT
finasteride, BPH, male pattern baldness
levels and bioavailability
__ in structure of AR alter physio responses to __ and __
CAG island between 12-32 Gln is ___
above 40, leads to ___
Repeats more common in A than H than C than A
Greater number repeats, ___ effective the receptor
Mutations can result in __ or ___ to T/DHT
Polymorphisms, T/DHT
normal
spinal/bulbar muscle atrophy
Asians, Hispanics, Caucasians, Africans
less
partial/complete insensitivity
__ provides negative feedback to hypothalamus on GnRH
Leuprolide is a ____ agonist
stimulates short term secretion of __ and ___
continued exposure disrupts ___ of GnRH, inhibiting ___ sec
Indications P P U E can also treat B B P
T
GnRH
LH/FSH, pulsatility, FSH/LH
Prostate cancer
PP
uterine leiomyoma
endometriosis
BPH
BC
prementrual syndrome
Ketoconzaole/Liarozole injibits steroidogenic p450s ___ and ____
Keto is an ___ antifungal
can disrupt synthesis of ___ and __ and ___
Differential inhibition leads to more selective inhibiton of ___
Indicated for ___
CSCC, 17A hydroxylase/lyase
imidazole, Aldo/cort/Testosterone
Prostate cancer
Finasteride
____ analog of T that acts as a ___, ___ inhibitor of ___ in the prostate, S___, E__, h____
Indicated for P/B/A
leads to reduction in __ but normal levels of ___
Flutamide/Cyproterone acetate/Spironolactone block NF to ____ and inc serum ___ by inc _____
act by inhibiting ___ in Hypo and DNA
As T levels rise, inhibitor effectiveness is ___
To decrease T/DHT action, combo therapy w __ or ___ can maximize effects
synthetic 4aza
competitive, selective, T25AR, seminal vesicles, epididymis, hair follicles
Prostate cancer, BPH, alopecia
DHT, T
HPA, LH, pulse freq
AR
compromised
GnRH, leuprolide
Flutamide
___ anti-androgen used as anti-hormone in tx of ____
most effective when combined w ___
Indicated for ___ and ___
virilization is a fxn of ___
can occur w ___ or low ___
Androgen replacement therapy can be useful for __ and ___
Nonsteroidal, Metastatic prostatic carcinoma
GnRH agonist, leuprolide
prostate cancer, BPH
relative steroid levels
high T, E2
osteoporosis, sex dysfxn (libido)
Testosterone is a schedule C3 controlled substance delivered as ___
names A and T
Indicated for ___ or ___ in men
such as ___
__ in postmenopausal women
can tx ___ assc w RF, AIDS assc ___, and ___ to ___ gender change
topical skin gel
Androgel, Testim
Congenital, acquired hypogonadism
delayed puberty
BC
Anemia, wasting syndrome, female to male
