Chemo Podcast

Question 1

Cisplatin

___ type drug, __ derived

Action is to ___ and __ DNA

SE- __ toxicity, can be suppressed w hydration
other __ SE

Administered via
Plasma t1/2 is

excreted __ in the ___

Answer 1

anti-neoplastic, platinum

crosslink/alkylate

renal
chemo

IV
25-50min

slowly, urine

Question 2

Bleomycin

Degraded by a specific __ low in the __ and ___

SE: __ toxicity, leads to ___ and/or __ and ___

Also ___

Lung problems start as ___ and progress

Probably due to toxicity of drug towards ___ in airways

Answer 2

hydrolase, skin/lungs

skin, skin thickening, stripes/itching

PF

dry cough

normal epithelial cells

Question 3

Anti-neoplastic hormonal agent ___

SE: H, N/V, H, V

2-3x inc risk of ___

Given ___, half life of ___

__ can also be taken orally

__ inhib of ___ used for ER+ BC

binds to ___ of CYP19
may be __ than tamoxifen

Anastrozole has few ___ and not assc w ___

Fromestane/exemestane are ___
Fxn as ___ irreversibly binding aromatase

Answer 3

tamoxifen

hot flashes, NV, hair loss, vaginal atrophy

endometrial cancer

orally, 7-14 days

anastrozole

nonsteroidal, aromatase

heme group, safer

SE, endometrial cancer

steroidal inhibitors
suicide inhibitors

Question 4

Doxorubicin/Bleomycin are products of ___ Steptomyces

Doxorubicin can be used against __ and __ tumors

Doxorubicin/ other rubicins inhibit ___, ___ DNA, bind to ___, generating ___

Doxorubicin SE
__ which can be treated w ____ that chelates Fe

Also turns urine __ during excretion

Answer 4

soil microbe

hematologic ca, solid

Topo2, intercalate, CM, free radicals

cardiotoxicity, dezroxane

red

Question 5

Anti-neoplastic alkylating drugs include __ and ___

transfer __ to DNA, resulting in __ and ___, which is toxic to ___

different drugs can modify __ of DNA

SE: toxic to ___

(CP) some are used to prevent __ after transplantation

Dacarbazine modified in liver to become ___
enzymes include __ and ___ and ____

__ limit its activity in vivo

Answer 5

dacarbazine, cyclophosphamide

alkyl groups, damage/crosslinks, dividing cells

distinct sites

bone marrow

organ rejection

diazomethane
CYP1A1, CYP1A2, CYP2E1

low levels

Question 6

Trastuzumab

antibody fragment that targets ____ aka

Her2 RTK heterodimerizes w ___, becoming active and drives ___

Trastuzumab binds to ___ while EGFR can be blocked by __/___

Cetuximab/erbitux is useful for other cancers w ___ elevation

___ can be used to block IC fxns of EGFR, Her2/neu

Answer 6

Her2neu, herceptin

EGFR, signaling

Her2neu
cetuximab/erbitux

EGFR

small molecule inhibitors