Sthapylococcus Flashcards
Sthapylococcus Grow in media containing
10% NaCl at temp 18 to 40 C
Staphylococcus Present on the
skin and mucus membrane
Staphylococcus Resistant to
drying and heat
Slime layer or capsule
What kind of layer
Polysaccharide
Slime layer or capsule
Protects bacteria
Inhibition of chemotaxis and phagocytosis
Slime layer or capsule
Facilitate adherence to
Catheters and synthetic materials
Slime layer or capsule
Covalently linked to
Peptidoglycans
Slime layer or capsule
Has affinity to
FC receptor of IG
Slime layer or capsule
Blocks
Opsonization and phagocytosis
Ribitol teichoic acid with N-acetylglucosamine (Polysaccharide A)
S. aureus
Glycerol teichoic acid with glucosyl residues (polysaccharide B)-
S. epidermidis
Disrupts smooth muscle in the blood vessel
Toxic to RBC, platelets, hepatocytes
Cause cell lysis-efflux of K, influx Na, Ca- osmosis
Septic shock
Alpha
Damage membrane of susceptible cells
Lyze neutrophils and macrophage
Cell lysis
Necrotizing skin infection
Gamma
Disrupts cell membrane
Toxic to variety of cells
Delta
Specific for sphingomyelin and lysophosphatidylcholine
Toxic to RBC, WBC, macrophage ,fibroblast
Tissue destruction and abscess formation
Beta
Sphingomyelinase C
Kills WBC, leucotoxic
Phanton valentine
Exfoliative toxin
Heat stable
ETA
Exfoliative toxin
Heat Labile
ETB
Exposure of exfoliative toxin
splitting of desmosomes or intercellular bridges in the stratum granulosum epidermis
Exfoliative toxin common in neonates. ETA and EBA binds to
GM4 like glycolipids
Entertoxin
A-E
G-I
Entertoxin are
Stable to heating
Resistant to hydrolysis
o – most commonly associated with disease
Enterotoxin A
- contaminated milk products
oEnterotoxin C and D
- Pseudomembranous colitis
oEnterotoxin B
TSST -1
Formerly pyrogenic
Exotoxin C
Entertoxin F
TSST -1
Induce cytokine release from
Macrophage and T cells
TSST -1
Increase sensitivity to
Endotoxin
TSST -1
Produce leakage of
Endothelial cells