Steroids Flashcards
aldosterone synthesis is stimulated by __________
angiotensin II and potassium
hydrocortisone
short-acting glucocorticoid
replacement therapy for cortisol
prednisolone
short-acting glucocorticoid
potent anti-inflammatory
dexamethasone
long acting glucocorticoid
Used to diagnose cortisol disorders
fludrocortisone
mineralocorticoid
adrenal steroids are ______________ and ______________. Steroids are all made from ____________.
glucocorticoids and mineralocorticoids
cholesterol
Which adrenal steroid is anti-inflammatory?
glucocorticoids
Which adrenal steroid affects water and electrolyte balance?
mineralocorticoids
which synthetic steroid has a high salt-retaining capacity?
fludrocortisone
which synthetic steroid is best to replace mineralocorticoid deficiency?
fludrocortisone
cortisol synthesis is stimulated by __________
ACTH
ACTH release the ______________ is stimulated by CRH and inhibited by ________ (negative feedback).
anterior pituitary
CRH (corticotropin releasing hormone) is released by the _____________ in response to stress or circadian rhythm.
hypothalamus
List effects of glucocorticoids on protein, glucose, and lipid metabolism.
Increase hepatic gluconeogenesis via skeletal muscle protein breakdown
Increase hepatic glycogenolysis
Redistribution of body fat
The effect of glucocorticoids on the immune system
suppress inflammatory immune response
glucocorticoid toxicity is unusual as long as course is less than ________(Time frame)
2 weeks
Abrupt withdrawal of exogenous glucocorticoids leads to:
acute adrenal insufficiency
Potential complications of long-term high dose steroids
osteoporosis
hypertension
increased susceptibility to infection
Cushing’s type syndrome (striae, acne, fat redistribution)
