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Pharmacology Exam 3 > Asthma/COPD Drugs > Flashcards

Asthma/COPD Drugs Flashcards

1
Q

systemic corticosteroid

A

methylprednisolone

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2
Q

aerosol corticosteroid

A

fluticasone

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3
Q

short acting beta agonists

A

albuterol

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4
Q

long acting beta agonist

A

salmeterol

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5
Q

short acting muscarinic antagonist

A

ipratropium bromide

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6
Q

long acting muscarinic antagonist

A

tiotropium

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7
Q

phosphodiesterase inhibitor

A

theophylline

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8
Q

leukotriene pathway inhibitor

A

montelukast

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9
Q

IgE inhibitor

A

omalizumab

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10
Q

what is the effect of mast cell activation on the airway?

A

decreased diameter

increased mucus secretion

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11
Q

drugs that affect airway responsiveness/reactivity for asthma

A

inhaled corticosteroids

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12
Q

drugs that affect airway resistance for asthma

A

short-acting bronchodilators

IV or PO steroids

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13
Q

adverse effect of inhaled corticosteroids

A

oral candidiasis

dysphonia

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14
Q

systemic adverse effects of high dose ICS or PO steroids

A

bone resorption
skin thinning
growth retardation
(suppresses HPA axis)

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15
Q

increase beta-2 receptors in airway

A

ICS

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16
Q

useful in asthma but not really in COPD

A

ICS

17
Q

can be used as mono therapy in COPD but NOT in asthma

A

LABAs

18
Q

adverse effects of LABAs

A

muscle tremor
tachycardia
hypokalemia
tolerance

19
Q

which drug class is not anti-inflammatory?

A

muscarinic antagonists

20
Q

can be useful in COPD but not really in asthma

A

muscarinic antagonists

21
Q

which drug inhibits vaguely mediated airway tone to produce bronchodilator?

A

muscarinic antagonists

22
Q

which drug relaxes airway smooth muscle and inhibits release of mast cell mediators?

A

beta-2 agonists

23
Q

adverse effects of muscarinic antagonists

A

dry mouth
urinary retention
few side effects because poorly absorbed

24
Q

which drug inhibits cAMP phosphodiesterase in smooth muscle?

A

theophylline

25
Q

which drug increases diaphragm muscle contractility in COPD?

A

theophylline

26
Q

adverse effects of theophylline

A

narrow therapeutic window, monitor plasma levels

cardio, CNS, and GI effects

27
Q

which drug is effective as an add on tx in aspirin-sensitive asthmatics?

A

leukotriene inhibitors

no role in COPD

28
Q

adverse effects of leukotriene inhibitors

A 
hepatic dysfunction
neuropsychiatric events (BBW)
29
Q

how to administer omalizumab

A

subcutaneous x 10 weeks

dose determined by serum IgE level

30
Q

downside of omalizumab

A

$$$$$$$$$$$$

wide variation in response

Pharmacology Exam 3 (10 decks)

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