Steps in the cholinergic synapse

Question 1

How many steps are in the cholinergic synapse?

Answer 1

4

Question 2

Depolarization in the synaptic knob casues the calcium channels to open up and calcium flows in.

Answer 2

step 1

Question 3

The calcium flowing in causes exocytosis of the synaptic vesicles that contain the neurotransmitter, ACh. Neurotransmitter diffuses into the synaptic cleft and binds to receptors.

Answer 3

Step 2

Question 4

In step 1 what causes the calcium channels to open up and calcium to flow in?

Answer 4

depolarization in the synaptic knob

Question 5

What does the calcium flowing in, in step 2 cause?

Answer 5

exocytosis of the synaptic vesicles that contain the neurotransmitter, ACh.

Question 6

In step 2 where does the neurotransmitter ACh go after exocytosis?

Answer 6

into the synaptic cleft and binds to receptors

Question 7

The receptors are also ligand-gated sodium channels that open up for the flow of sodium.

Answer 7

Step 3

Question 8

ACh is removed by acetylcholinesterase

Answer 8

Step 4

Question 9

What is ACh removed by in step 4?

Answer 9

acetylcholinesterase

Question 10

In step 3 what type of channels are they and why do they open?

Answer 10

ligand-gated sodium channels

open for flow of sodium

Question 11

When is an action potential generated?

Answer 11

if threshold is met

Question 12

What are the 3 fates of the neurotransmitter?

Answer 12

1. diffusion because of the space in between
2. degradation by an enzyme
3. uptake by cells

Question 13

Occurs during chemical synapses because the neurotransmitter must be released and the trigger for that is calcium flow

Answer 13

synaptic delay

Question 14

When do synaptic delays occur?

Answer 14

during chemical synapses

Question 15

What is the trigger for the synaptic delay?

Answer 15

calcium flow

Question 16

Why does the synaptic delay happen?

Answer 16

becuase the neurotransmitter must be released