Stem Cells Lec 2

Question 1

Where are stem cells located?

Answer 1

Basal layer of skin

Question 2

Characteristics of embryonic stem cells

Answer 2

pluripotent, grow continuously, abundant, great potential

Question 3

Characteristics of adult stem cells

Answer 3

tissue specific, multipotent (form certain cell types), limited life span in culture, limited numbers

Question 4

When do stem cells proliferate?

Answer 4

fetal development and wound healing

Question 5

SC Transit Amplifying concept

Answer 5

Slow cycling stem cells occasionally divide. One daughter cell remains a SC. The other becomes a TA cell. TA cells divide several cycles. TA cells become post mitotic, terminal differentiation occurs.

Question 6

3 sites of epidermal stem cells

Answer 6

Interfollicular epidermis, bulge region of outer root sheath of hair follicle, and sebaceous gland.

Question 7

Epidermal Stem Cells

Answer 7

responsible for everyday regeneration of the different layers of the epidermis.

Question 8

Hair Follicle Stem Cells

Answer 8

ensure constant renewal of the hair follicles. They can also regenerate the epidermis and sebaceous glands if these tissues are damaged. Hair follicle stem cells are found throughout hair follicles.

Question 9

Melanocyte stem cells

Answer 9

responsible for regeneration of melanocytes, a type of pigment cell. Produce melanin and therefore melanocytes play an important role in skin and hair follicle pigmentation. It is not yet certain where these stem cells are found in humans.

Question 10

What happens if you put a fully differentiated cell into differentiated tissues?

Answer 10

Cell will not intergrate

Question 11

What happens if you put a fully differentiated cell nucleus in a cell of differentiated tissues?

Answer 11

Cell will fully integrate. The cell nucleus contains all information required to make a new tissue or organ