Quiz Questions Flashcards
What is the major lipid macromolecular phase found in the lower part of the stratum?
Orthorhombic structure
What is the main template lipid covalently bound to the outer protein of the cornified envelops?
𝛚-OH Ceramide
Which proteins are found in the fully differentiated cornified envelope?
- Loricrin
- Keratin 1
- Keratin 10
- Involucrin
- Ceramide 1
Name an active that can enhance penetration of drugs into the nail plate.
- Urea
- Ammonium thioglycolate
- Acetyl cysteine
What is a surfactant?
Surface active agent - reduces interfacial tension by its tendency to absorb at interface
Why does irritation potential fall when a harsher surfactant is mixed with a more mild surfactant?
There is a reduction in CMC and monomer concentration, so irritation is minimal
Surfactants that can be part of a syndet bar
Stearic acid, cocomonoglyceride sulfate, soap
What does the corneometer measure?
Moisture content of the skin by measuring dielectric constant
What test is the gold standard for documenting the efficacy of a moisturizer?
Kligman Leg Regression Test
How many days of treatment for the Kligman method is required so it can differentiate superior products to a competitor?
21 Days
What time of the year must this study be conducted?
winter
What bio-instruments can be used to measure skin elasticity/firmness?
Cutometer, dermal torque meter, ballistometer
What are the pathways of allergen/hapten absorption?
- Trancellular
- Intercellular
- Appendageal
What epidermal cells are responsible for immune response to haptens?
Langerhan’s cells
What kind of proteins can be found in the cortex of the hair shaft?
Keratin Associated proteins
